Evidence map›Paper›PMID 29734748›Full record

ArticleInternational journal of molecular sciences2018

Enhanced Homing Technique of Mesenchymal Stem Cells Using Iron Oxide Nanoparticles by Magnetic Attraction in Olfactory-Injured Mouse Models.

Wan Su Yun, Jin Sil Choi, Hyun Mi Ju, Min Hee Kim, Seong Jin Choi, Eun Seol Oh, Young Joon Seo, Jaehong Key

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. Bioprinting for bone tissue engineering.Frontiers in bioengineering and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wan Su YunDepartment of Biomedical Engineering, Yonsei University, Wonju, Gangwon-do 26493, Korea. ip9801@naver.com.
Jin Sil ChoiLaboratory of Smile Snail, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea. towtowtow92@naver.com.
Hyun Mi JuLaboratory of Smile Snail, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea. skdi1082@naver.com.
Min Hee KimLaboratory of Smile Snail, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea. mini.aclice11234@gmail.com.
Seong Jin ChoiDepartment of Obstetrics and Gynecology, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea. choisj@yonsei.ac.kr.
Eun Seol OhDepartment of Biomedical Engineering, Yonsei University, Wonju, Gangwon-do 26493, Korea. marchman10@hanmail.net.
Young Joon SeoLaboratory of Smile Snail, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea. okas2000@hanmail.net.ORCID 0000-0002-2839-4676
Jaehong KeyDepartment of Biomedical Engineering, Yonsei University, Wonju, Gangwon-do 26493, Korea. jkey@yonsei.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intranasal delivery of mesenchymal stem cells (MSCs) to the olfactory bulb is a promising approach for treating olfactory injury. Additionally, using the homing phenomenon of MSCs may be clinically applicable for developing therapeutic cell carriers. Herein, using superparamagnetic iron oxide nanoparticles (SPIONs) and a permanent magnet, we demonstrated an enhanced homing effect in an olfactory model. Superparamagnetic iron oxide nanoparticles with rhodamine B (IRBs) had a diameter of 5.22 ± 0.9 nm and ζ-potential of +15.2 ± 0.3 mV. IRB concentration of 15 µg/mL was injected with SPIONs into MSCs, as cell viability significantly decreased when 20 μg/mL was used (

Indexed as

AnimalsCell DifferentiationCell SurvivalChemokine CXCL12Disease Models, AnimalFerric CompoundsMagnetic Resonance ImagingMagnetite NanoparticlesMesenchymal Stem CellsMiceOlfactory BulbReceptors, CXCR4RhodaminesSignal TransductionChemokine CXCL12Cxcl12 protein, mouseCXCR4 protein, mouseFerric Compoundsferric oxideMagnetite NanoparticlesReceptors, CXCR4RhodaminesCXCR4homingintranasal deliverymesenchymal stem cellsolfactory-injured mouse modelsuperparamagnetic iron oxide nanoparticles

Identifiers

PMID29734748
PMCPMC5983763

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.