Evidence map›Paper›PMID 29734741›Full record

ArticleMolecules (Basel, Switzerland)2018

Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines.

Natarajan Arumugam, Abdulrahman I Almansour, Raju Suresh Kumar, Periyasami Govindasami, Dhaifallah M Al-Thamili, Rajapandian Krishnamoorthy, Vaiyapuri Subbarayan Periasamy, Ali A Alshatwi, S M Mahalingam, Shankar Thangamani and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Natarajan ArumugamDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. anatarajan@ksu.edu.sa.ORCID 0000-0001-9073-155X
Abdulrahman I AlmansourDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. almansor@ksu.edu.sa.
Raju Suresh KumarDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. sraju@ksu.edu.sa.
Periyasami GovindasamiDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. pkandhan@ksu.edu.sa.ORCID 0000-0003-1181-1645
Dhaifallah M Al-ThamiliDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. daife54321@hotmail.com.
Rajapandian KrishnamoorthyNanobiotecnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh 11451, Saudi Arabia. rjpandiyank@gmail.com.
Vaiyapuri Subbarayan PeriasamyDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907-2084, USA. vsperrys@gmail.com.
Ali A AlshatwiNanobiotecnology and Molecular Biology Research Laboratory, Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University, Riyadh 11451, Saudi Arabia. alshatwi@ksu.edu.sa.
S M MahalingamDepartment of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907-2084, USA. mahalins@purdue.edu.
Shankar ThangamaniDepartment of Pathology and Population Medicine, College of Veterinary Medicine, Midwestern University, Glendale, AZ 85308, USA. sthang@midwestern.edu.
J Carlos MenéndezUnidad de Química Orgánica y Farmacéutica, Departamento de Química en Ciencias Farmacéuticas, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain. josecm@farm.ucm.es.ORCID 0000-0002-0560-8416
King Saud University · SAPurdue University West Lafayette · USMidwestern University · USUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of spirooxindolopyrrolidine fused

Indexed as

Antineoplastic AgentsApoptosisBinding SitesBleomycinCell Line, TumorCell SurvivalCycloaddition ReactionDrug DesignHumansImidazolesIndolesInhibitory Concentration 50LymphocytesMolecular Docking SimulationPiperidonesProtein Binding1-butyl-3-methylimidazolium chlorideAntineoplastic AgentsBleomycinImidazolesIndolesMET protein, humanPiperidonesProto-Oncogene Proteins c-metPyrrolidinesSpiro Compounds1,3-dipolar cycloadditioncytotoxicity assaysdomino reactionionic liquidsmolecular docking

Identifiers

PMID29734741
PMCPMC6100567
OpenAlexW2799849386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.