ArticleAnimals : an open access journal from MDPI2018
Single Nucleotide Polymorphisms in the HIRA Gene Affect Litter Size in Small Tail Han Sheep.
Article in Animals : an open access journal from MDPI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Novel Silent Mutations in theAnimals : an open access journal from MDPI · 2025Article
- Association Analysis of SNPs inAnimals : an open access journal from MDPI · 2025Article
- Single nucleotide polymorphism-based analysis of linkage disequilibrium and runs of homozygosity patterns of indigenous sheep in the southern Taklamakan desert.BMC genomics · 2025Article
- Association analysis of single nucleotide polymorphisms in the LIFR gene with lambing number in sheep.Frontiers in veterinary science · 2025Article
- Screening of Litter-Size-Associated SNPs inAnimals : an open access journal from MDPI · 2024Article
- Association Analyses between Single Nucleotide Polymorphisms inAnimals : an open access journal from MDPI · 2023Article
- Genome wide identification and characterization of fertility associated novel CircRNAs as ceRNA reveal their regulatory roles in sheep fecundity.Journal of ovarian research · 2023Article
- The Significance of a Multilocus Analysis for Assessing the Biodiversity of the Romanov Sheep Breed in a Comparative Aspect.Animals : an open access journal from MDPI · 2023Article
- Expression characteristics of piRNAs in ovine luteal phase and follicular phase ovaries.Frontiers in veterinary science · 2022Article
- The effect of SNP rs400827589 in exon 2 of the MTNR1B gene on reproductive seasonality and litter size in sheep.Veterinary medicine and science · 2020Article
- TGIF1 and SF1 polymorphisms are associated with litter size in Small Tail Han sheep.Reproduction in domestic animals = Zuchthygiene · 2020Article
- Mutations inAnimals : an open access journal from MDPI · 2020Article
- Myostatin (MSTN) Gene Indel Variation and Its Associations with Body Traits in Shaanbei White Cashmere Goat.Animals : an open access journal from MDPI · 2020Article
- Polymorphisms of the melatonin receptor 1A gene that affects the reproductive seasonality and litter size in Small Tail Han sheep.Reproduction in domestic animals = Zuchthygiene · 2019Article
- Single Nucleotide Polymorphisms inAnimals : an open access journal from MDPI · 2019Article
- Molecular Cloning of theAnimals : an open access journal from MDPI · 2018Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintenance of appropriate levels of fecundity is critical for efficient sheep production. Opportunities to increase sheep litter size include identifying single gene mutations with major effects on ovulation rate and litter size. Whole-genome sequencing (WGS) data of 89 Chinese domestic sheep from nine different geographical locations and ten Australian sheep were analyzed to detect new polymorphisms affecting litter size. Comparative genomic analysis of sheep with contrasting litter size detected a novel set of candidate genes. Two SNPs, g.71874104G>A and g.71833755T>C, were genotyped in 760 Small Tail Han sheep and analyzed for association with litter size. The two SNPs were significantly associated with litter size, being in strong linkage disequilibrium in the region 71.80⁻71.87 Mb. This haplotype block contains one gene that may affect litter size, Histone Cell Cycle Regulator (
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