ArticlePLoS genetics2018
A coupled process of same- and opposite-sex mating generates polyploidy and genetic diversity in Candida tropicalis.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- An agricultural triazole induces genomic instability and haploid cell formation in the human fungal pathogen Candida tropicalis.PLoS biology · 2025Article
- In Vivo Microevolutionary Analysis of a Fatal Case of Rhinofacial and Disseminated Mycosis Due to Azole-Drug-Resistant Candida Species.Journal of fungi (Basel, Switzerland) · 2023Article
- Ploidy Variation and Spontaneous Haploid-Diploid Switching of Candida glabrata Clinical Isolates.mSphere · 2022Article
- Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Phenotypic Switching and Filamentation in Candida haemulonii, an Emerging Opportunistic Pathogen of Humans.Microbiology spectrum · 2021Article
- Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples.PLoS pathogens · 2021Article
- Is Natural Population ofFrontiers in cellular and infection microbiology · 2021Review
- Parasexuality ofFrontiers in cellular and infection microbiology · 2021Review
- Is Candida auris sexual?PLoS pathogens · 2020Review
- Advances in understanding the evolution of fungal genome architecture.F1000Research · 2020Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexual reproduction is a universal mechanism for generating genetic diversity in eukaryotes. Fungi exhibit diverse strategies for sexual reproduction both in nature and in the laboratory. In this study, we report the discovery of same-sex (homothallic) mating in the human fungal pathogen Candida tropicalis. We show that same-sex mating occurs between two cells carrying the same mating type (MTLa/a or α/α) and requires the presence of pheromone from the opposite mating type as well as the receptor for this pheromone. In ménage à trois mating mixes (i.e., "a x a + α helper" or "α x α + a helper" mixes), pheromone secreted by helper strains promotes diploid C. tropicalis cells to undergo same-sex mating and form tetraploid products. Surprisingly, however, the tetraploid mating products can then efficiently mate with cells of the opposite mating type to generate hexaploid products. The unstable hexaploid progeny generated from this coupled process of same- and opposite-sex mating undergo rapid chromosome loss and generate extensive genetic variation. Phenotypic analysis demonstrated that the mating progeny-derived strains exhibit diverse morphologies and phenotypes, including differences in secreted aspartic proteinase (Sap) activity and susceptibility to the antifungal drugs. Thus, the coupling of same- and opposite-sex mating represents a novel mode to generate polyploidy and genetic diversity, which may facilitate the evolution of new traits in C. tropicalis and adaptation to changing environments.
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