Evidence map›Paper›PMID 29734234›Full record

ArticleAmerican journal of physical medicine & rehabilitation2018

Two-Year Longitudinal Changes in Lower Limb Strength and Its Relation to Loss in Function in a Large Cohort of Patients With Duchenne Muscular Dystrophy.

Abhinandan Batra, Ann Harrington, Donovan J Lott, Rebecca Willcocks, Claudia R Senesac, William McGehee, Dandan Xu, Sunita Mathur, Michael J Daniels, William D Rooney and 13 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physical medicine & rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 1 institution in 1 country.

Abhinandan BatraFrom the Department of Physical Therapy, University of Florida, Gainesville, Florida (AB, DJL, RW, CRS, WM, SCF, WT, JKD, KV); Department of Physical Therapy, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (AH); Department of Statistics, University of Florida, Gainesville, Florida (DX, MJD); Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada (SM); Advanced Imaging Research Center, Oregon Health and Science University, Portland, Oregon (WDR); Department of Neurology, Oregon Health and Science University, Portland, Oregon (IA); Department of Occupational Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania (RB); Department of Pediatrics, Nemours Children's Hospital, Orlando, Florida (RF); Department of Pediatrics, Oregon Health and Science University, Portland, Oregon (EF); Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (GT); Department of Pediatrics, University of Florida, Gainesville, Florida (BB); Division of Neurology, Oregon Health and Science University, Portland, Oregon (BR); Department of Pharmacology and Therapeutics, University of Florida, Gainesville, Florida (HLS); and Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida (GW).
Ann Harrington
Donovan J Lott
Rebecca Willcocks
Claudia R Senesac
William McGehee
Dandan Xu
Sunita Mathur
Michael J Daniels
William D Rooney
Sean C Forbes
William Triplett
Jasjit K Deol
Ishu Arpan
Roxanne Bendixen
Richard Finkel
Erika Finanger
Gihan Tennekoon
Barry Byrne
Barry Russman
H Lee Sweeney
Glenn Walter
Krista Vandenborne
Children's Hospital of Philadelphia · US

Funding

Training and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1M
Magnetic Resonance Imaging and Biomarkers for Muscular DystropyR01AR056973 · NIAMS · UNIVERSITY OF FLORIDA · PI VANDENBORNE, KRISTA H · 2010 to 2024
$20.2M
NIAMS NIH HHS R01 AR056973NIAMS NIH HHS U54 AR052646
6 · The paper itself

Abstract

objectiveThe main objective of this study was to examine the effect of disease on strength in two functionally important lower limb muscles for a period of 2 yrs in children with Duchene muscular dystrophy.

designSeventy-seven Duchene muscular dystrophy children participated in this study. Plantar flexors, knee extensors, strength, and performance on timed tests (6-min walk, 4-stairs, 10-m walk, supine-up) were assessed yearly for 2 yrs. Multivariate normal regression was used to assess changes in strength over time in the Duchene muscular dystrophy group. Spearman correlations were computed to examine relationship between strength and function.

resultsNormalized plantar flexor and knee extensor strength showed a significant decrease (P < 0.05) over 2 yrs, with larger declines in knee extensor. At baseline, knee extensor strongly correlated with performance on timed tests. However, plantar flexor strength was found to be a stronger predictor of loss in ambulatory function. Modest correlations (r = 0.19-0.34) were found between the decline in strength and functional performance over 2 yrs.

conclusionsThis study describes the loss of lower limb strength in a large cohort of Duchene muscular dystrophy children for 2 yrs. The findings support that lower limb strength alone cannot account for the decline in performance on functional tests, and the role of other contributing factors, such as compensatory strategies, should be considered.

Indexed as

Physical Functional PerformanceChildChild, PreschoolCohort StudiesFemaleHumansKneeLongitudinal StudiesLower ExtremityMaleMuscle, SkeletalMuscle StrengthMuscular Dystrophy, DuchenneTime FactorsWalk Test

Identifiers

PMID29734234
PMCPMC6148402
OpenAlexW2801246042

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.