Observational studyGastroenterology2018
Genesis of Esophageal Pressurization and Bolus Flow Patterns in Patients With Achalasia Esophagus.
Observational study in Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Esophageal peristalsis in health and disease: mechanistic insights.Physiological reviews · 2026Review
- Functional-Structural Correlates in Achalasia: The Relationship of Esophageal Pressurization and Anatomy.Neurogastroenterology and motility · 2025Article
- Additional Diagnostic Yield of Ambulatory 24-h High Resolution Manometry With Impedance in Patients With Non-Cardiac Chest Pain or Non-Obstructive Dysphagia.Neurogastroenterology and motility · 2025Article
- Factors associated with the development of bacterial pneumonia and the preventive potential of peroral endoscopic myotomy in patients with esophageal motility disorders: a case-control study.Journal of gastroenterology · 2025Article
- Esophageal Symptoms and Lumbosacral Back Pain.Gastro hep advances · 2024Article
- Why so Many Patients With Dysphagia Have Normal Esophageal Function Testing.Gastro hep advances · 2024Article
- Mini-review: Tailored per-oral endoscopic myotomy for type III achalasia.Neurogastroenterology and motility · 2023Review
- Impaired sliding between the lower esophageal sphincter and crural diaphragm (esophageal hiatus) in patients with achalasia esophagus.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Identifying spastic variant of type II achalasia after treatment with high-resolution manometry and FLIP Panometry.Neurogastroenterology and motility · 2023Article
- Type II achalasia with focal elevated pressures: A distinct manometric and clinical sub-group.Neurogastroenterology and motility · 2022Article
- Distension contraction plots of pharyngeal/esophageal peristalsis: next frontier in the assessment of esophageal motor function.American journal of physiology. Gastrointestinal and liver physiology · 2022Review
- Esophageal Motility Disorders: Current Approach to Diagnostics and Therapeutics.Gastroenterology · 2022Review
- Morphologic Changes in Esophageal Body Movement During Bolus Transport After Peroral Endoscopic Myotomy in Type III Achalasia.Journal of neurogastroenterology and motility · 2022Article
- Validation of secondary peristalsis classification using FLIP panometry in 741 subjects undergoing manometry.Neurogastroenterology and motility · 2022Article
- Distension-contraction profile of peristalsis in patients with nutcracker esophagus.Neurogastroenterology and motility · 2021Article
- Achalasia subtypes can be identified with functional luminal imaging probe (FLIP) panometry using a supervised machine learning process.Neurogastroenterology and motility · 2021Article
- Relationship between distension-contraction waveforms during esophageal peristalsis: effect of bolus volume, viscosity, and posture.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- The rhythm and rate of distension-induced esophageal contractility: A physiomarker of esophageal function.Neurogastroenterology and motility · 2020Article
- An Animal Study of Implantation of an Esophageal Pacemaker Based on Per-Oral Endoscopic Myotomy Approach for Alleviation of Esophageal Peristalsis Disorders.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Neuronal Control of Esophageal Peristalsis and Its Role in Esophageal Disease.Current gastroenterology reports · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
BACKGROUND &
aimsIn patients with achalasia esophagus, swallows induce simultaneous pressure waves known as esophageal pressurization. We studied the mechanism of esophageal pressurization and bolus flow patterns in patients with type 2 or type 3 achalasia.
methodsWe recorded high-resolution manometry with impedance and intraluminal ultrasound images concurrently in patients with type 2 achalasia (n = 6) or type 3 achalasia (n = 8) and in 10 healthy subjects (controls) during swallows of 5 mL of 0.5N saline. For each swallow, the ultrasound image was aligned with the pressure and impedance tracings to determine cavity and contact pressure, bolus arrival, bolus dwell time, and changes in muscle thickness at 5 cm and 10 cm above the lower esophageal sphincter.
resultsIn patients with type 2 achalasia, esophageal pressurization was associated with an increase in the muscle thickness and luminal narrowing but not complete luminal closure (ie, cavity pressure). Bolus arrival time in the distal esophagus after the onset of a swallow was delayed in patients with type 3 achalasia compared with control individuals because of early luminal closure. The early luminal closure was associated with a decrease in the muscle thickness. The bolus dwell time was shorter in patients with type 3 achalasia compared with control individuals. In patients with type 3 achalasia, the onset of simultaneous pressure wave was always a cavity pressure, but during contraction there were different periods of cavity and contact pressures in association with increases in muscle thickness that resulted in bolus segmentation.
conclusionsWe observed distinct mechanisms of esophageal pressurization and bolus flow patterns in patients with type 2 or type 3 achalasia esophagus compared with control individuals. These findings will increase our understanding of the mechanisms of dysphagia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.