Evidence map›Paper›PMID 29733807›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2018

Fractal regulation and incident Alzheimer's disease in elderly individuals.

Peng Li, Lei Yu, Andrew S P Lim, Aron S Buchman, Frank A J L Scheer, Steven A Shea, Julie A Schneider, David A Bennett, Kun Hu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. BAILA: A Randomized Controlled Trial of Latin Dancing to Increase Physical Activity in Spanish-Speaking Older Latinos.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022
    Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Peng LiDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: pli9@bwh.harvard.edu.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Andrew S P LimDivision of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Aron S BuchmanRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Frank A J L ScheerDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA.
Steven A SheaOregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, OR, USA.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Kun HuDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: khu@bics.bwh.harvard.edu.
Rush University Medical Center · USCircadian (United States) · USBrigham and Women's Hospital · USHealth Sciences Centre · CAOregon Health & Science University · US

Funding

EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
TRANSPLANTATION ANALYSIS OF CIRCADIAN RHYTHMS AND AGINGP01AG009975 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI SAPER, CLIFFORD B · 1991 to 2018
$23.1M
Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK102696 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2015 to 2019
$3.8M
Sleep, Circadian Rhythms, and Mechanisms of Cognitive Decline in the Human BrainR01AG052488 · NIA · SUNNYBROOK RESEARCH INSTITUTE · PI LIM, ANDREW · 2017 to 2021
$3.3M
Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2M
Meal Time Effects on Metabolic Health.R01DK099512 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2014 to 2017
$2.8M
Development of countermeasures against adverse metabolic effects of shift workR01HL118601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2014 to 2017
$2.6M
The Clinical Profile of Parkinson's Disease (PD) PathologyR01NS078009 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI BUCHMAN, ARON S · 2012 to 2016
$2.4M
Neuropathology for disrupted multiscale activity control in Alzheimer's diseaseR01AG048108 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2015 to 2018
$1.6M
Fractal Regulatory Function of the Circadian SystemR00HL102241 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2012 to 2014
$720k
NHLBI NIH HHS R00 HL102241NHLBI NIH HHS R01 HL118601NIA NIH HHS P01 AG009975NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG048108NIA NIH HHS R01 AG052488NIDDK NIH HHS R01 DK099512NIDDK NIH HHS R01 DK102696NIDDK NIH HHS R01 DK105072NINDS NIH HHS R01 NS078009
6 · The paper itself

Abstract

introductionHealthy physiological systems exhibit fractal regulation (FR), generating similar fluctuation patterns in physiological outputs across different time scales. FR in motor activity is degraded in dementia, and the degradation correlates to cognitive decline. We tested whether degraded FR predicts Alzheimer's dementia.

methodsFR in motor activity was assessed in 1097 nondemented older adults at baseline. Cognition was assessed annually for up to 11 years.

resultsParticipants with an FR metric at the 10th percentile in this cohort had a 1.8-fold Alzheimer's disease risk (equivalent to the effect of being ∼5.2 years older) and 1.3-fold risk for mild cognitive impairment (equivalent to the effect of being ∼3.0 years older) than those at the 90th percentile. Consistently, degraded FR predicted faster cognitive decline. These associations were independent of physical activity, sleep fragmentation, and stability of daily activity rhythms. DISCUSSION: FR may be a useful tool for predicting Alzheimer's dementia.

Indexed as

Motor ActivityActigraphyAgedAged, 80 and overAlzheimer DiseaseCognitionCognition DisordersFemaleFractalsHumansLongitudinal StudiesMaleNeuropsychological TestsPrognosisFractal physiologyFractal regulationLongitudinal cohort studyMild cognitive impairmentPrediction of Alzheimer's disease

Identifiers

PMID29733807
PMCPMC6201319
OpenAlexW2802028197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.