Evidence map›Paper›PMID 29733744›Full record

ArticlePlatelets2019

Dyslipidemia-associated atherogenic oxidized lipids induce platelet hyperactivity through phospholipase Cγ2-dependent reactive oxygen species generation.

Martin Berger, Katie Wraith, Casey Woodward, Ahmed Aburima, Zaher Raslan, Matthew S Hindle, Julia Moellmann, Maria Febbraio, Khalid M Naseem

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Platelets, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Targeting Cysteine Oxidation in Thrombotic Disorders.Antioxidants (Basel, Switzerland) · 2024
    Review
  6. Review
  7. Review
  8. Redox Mechanisms of Platelet Activation in Aging.Antioxidants (Basel, Switzerland) · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. CD36 signaling in vascular redox stress.Free radical biology & medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Martin Bergera Centre for Atherothrombosis and Metabolic Disease, Hull-York Medical School , Faculty of Health Sciences, University of Hull , Hull , UK.
Katie Wraitha Centre for Atherothrombosis and Metabolic Disease, Hull-York Medical School , Faculty of Health Sciences, University of Hull , Hull , UK.
Casey Woodwarda Centre for Atherothrombosis and Metabolic Disease, Hull-York Medical School , Faculty of Health Sciences, University of Hull , Hull , UK.
Ahmed Aburimaa Centre for Atherothrombosis and Metabolic Disease, Hull-York Medical School , Faculty of Health Sciences, University of Hull , Hull , UK.
Zaher Raslanb Leeds Institute of Cardiovascular & Metabolic Medicine , The LIGHT Laboratories, University of Leeds , Leeds , UK.
Matthew S Hindleb Leeds Institute of Cardiovascular & Metabolic Medicine , The LIGHT Laboratories, University of Leeds , Leeds , UK.
Julia Moellmannc Department of Internal Medicine 1 , University Hospital RWTH Aachen , Aachen , Germany.
Maria Febbraiod School of Dentistry , University of Alberta , Edmonton , AB , Canada.
Khalid M Naseemb Leeds Institute of Cardiovascular & Metabolic Medicine , The LIGHT Laboratories, University of Leeds , Leeds , UK.
University of Leeds · GBRWTH Aachen University · DEUniversity of Hull · GBHull York Medical School · GBUniversity of Alberta · CA

Funding

British Heart Foundation PG/11/37/28884British Heart Foundation PG/12/49/29441British Heart Foundation PG/13/90/30578British Heart Foundation RG/16/5/32250
6 · The paper itself

Abstract

Oxidized low-density lipoprotein (oxLDL) and associated oxidized phosphocholine-headgroup phospholipids (oxPCs) activate blood platelets through ligation of the scavenger receptor CD36. Previously, we found that oxLDL stimulated phosphorylation of phospholipase Cγ2 (PLCγ2). However, the functional relevance of PLCγ2 phosphorylation in oxLDL-mediated platelet hyperactivity remained elusive. Here, we set out to explore the functional importance of PLCγ2 in oxLDL-mediated platelet activation using human and genetically modified murine platelets. The CD36-specific oxidized phospholipid (oxPC

Indexed as

AnimalsDyslipidemiasHumansLipoproteins, LDLMicePhospholipase C gammaPlatelet ActivationReactive Oxygen SpeciesLipoproteins, LDLoxidized low density lipoproteinPhospholipase C gammaReactive Oxygen SpeciesOxLDLoxPCplatelet hyperactivityPLCγ2reactive oxygen species

Identifiers

PMID29733744
PMCPMC6457275
OpenAlexW2800028343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.