Evidence map›Paper›PMID 29733639›Full record

ArticleACS chemical biology2018

Visualizing the Brain's Astrocytes with Diverse Chemical Scaffolds.

Alyssa N Preston, Joshua D Farr, Brianna K O'Neill, Kaitlyn K Thompson, Stella E Tsirka, Scott T Laughlin

Abstract read
In one paragraph

Article in ACS chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Blood-brain-barrier permeable fluorescent astrocyte probes.bioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Design Principles for Cationic, Astrocyte-Targeted Probes.Chembiochem : a European journal of chemical biology · 2019
    Article
  7. Visualizing the brain's astrocytes.Methods in enzymology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alyssa N PrestonDepartment of Chemistry , Stony Brook University , Stony Brook , New York 11794 , United States.ORCID 0000-0002-4818-8706
Joshua D FarrDepartment of Chemistry , Stony Brook University , Stony Brook , New York 11794 , United States.
Brianna K O'NeillDepartment of Chemistry , Stony Brook University , Stony Brook , New York 11794 , United States.ORCID 0000-0003-0735-4015
Kaitlyn K ThompsonDepartment of Pharmacological Sciences , Stony Brook University , Stony Brook , New York 11794 , United States.
Stella E TsirkaDepartment of Pharmacological Sciences , Stony Brook University , Stony Brook , New York 11794 , United States.
Scott T LaughlinDepartment of Chemistry , Stony Brook University , Stony Brook , New York 11794 , United States.ORCID 0000-0002-9134-1200

Funding

SBU Chemistry-Biology Interface Training ProgramT32GM092714 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI SAMPSON, NICOLE S, TONGE, PETER J · 2010 to 2019
$1.7M
NIGMS NIH HHS T32 GM092714
6 · The paper itself

Abstract

Astrocytes are the most abundant cells in the brain. They support neurons, adjust synaptic strength, and modulate neuronal signaling, yet the full extent of their functions is obscured by the dearth of methods for their visualization and analysis. Here, we report a chemical reporter that targets small molecules specifically to astrocytes both in vitro and in vivo. Fluorescent versions of this tag are imported through an organic cation transporter to label glia across species. The structural modularity of this approach will enable wide-ranging applications for understanding astrocyte biology.

Indexed as

AnimalsAstrocytesBrainFluorescenceFluorescent DyesHEK293 CellsHumansMiceMicroscopy, ConfocalPyridinium CompoundsRatsRhodaminesSpinal CordZebrafish4-(4-diethylaminostyryl)-N-methylpyridiniumFluorescent DyesPyridinium CompoundsRhodamines

Identifiers

PMID29733639
PMCPMC6287642

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.