ArticleInternational journal of epidemiology2018
Growth parameters at birth mediate the relationship between prenatal manganese exposure and cognitive test scores among a cohort of 2- to 3-year-old Bangladeshi children.
Article in International journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Less continuity with more complaints: a repeated cross-sectional study of the association between relational continuity of care and patient complaints in English general practice.BMJ quality & safety · 2026Article
- Environmental Toxicants and the Developing Brain.Biological psychiatry · 2023Review
- Exposure of preterm neonates receiving total parenteral nutrition to phthalates and its impact on neurodevelopment at the age of 2 months.Scientific reports · 2023Article
- Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh.Environment international · 2022Article
- Application of 4-way decomposition to the analysis of placental-fetal biomarkers as intermediary variables between maternal body mass index and birthweight.Frontiers in reproductive health · 2022Article
- High Concentration of Heavy Metal and Metalloid Levels in EdibleInternational journal of environmental research and public health · 2021Article
- Development, validation and utilisation of dish-based dietary assessment tools: a scoping review.Public health nutrition · 2021Article
- Stunting and lead: using causal mediation analysis to better understand how environmental lead exposure affects cognitive outcomes in children.Journal of neurodevelopmental disorders · 2020Article
- Gestational weight gain and newborn anthropometric outcomes in rural Bangladesh.Maternal & child nutrition · 2019Article
- Quantification of Elemental Contaminants in Unregulated Water across Western Navajo Nation.International journal of environmental research and public health · 2019Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Background: Our previous study demonstrated that prenatal manganese exposure is associated with cognitive test scores among a cohort of 2- to 3-year-old Bangladeshi children. This study tested the hypothesis that the adverse effects of manganese are mediated through poor prenatal growth. Methods: Pregnant mothers were enrolled in a birth cohort in Bangladesh between 2008 and 2011, and children were followed at birth and age 20-40 months. Manganese concentration was measured in umbilical cord blood. Anthropometric measurements (weight, length, head circumference) were assessed at delivery. Children's cognitive development was assessed at age 20-40 months using the Bayley Scales of Infant and Toddler Development-Third Edition. Using recently developed statistical approaches that estimate mediation and interaction effects simultaneously, we evaluated whether the association between cord blood manganese and cognitive score was mediated through anthropometric measures at birth. Results: This analysis included 764 mother-child pairs. Higher manganese concentration was associated with lower cognitive score [β=-0.61, standard error (SE)=0.23, p = 0.009]. Among the birth measures, we found a significant indirect effect only through birth length (β =-0.10, SE = 0.03, p = 0.001). We also found evidence of mediated interaction (both mediation and interaction, β =-0.03, SE = 0.01, p = 0.01) with birth length in the association between cord blood manganese and cognitive score. The overall proportion mediated by birth length was 33% (p = 0.02) and the proportion attributed to interaction was 11% (p = 0.04). We did not find evidence of a mediating effect through birth weight or head circumference. Conclusions: Our findings confirm that prenatal growth, particularly birth length, contributes to the overall effect of environmental manganese exposure on a child's cognitive development.
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