ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Mortality in Relation to Changes in a Healthy Aging Index: The Health, Aging, and Body Composition Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relationship Between Successful Aging and All-Cause Mortality Risk in Older Adults: A Systematic Review and Meta-Analysis of Cohort Studies.Frontiers in medicine · 2021Pooled it
- Yoga-based lifestyle intervention for healthy ageing in older adults: a two-armed, waitlist randomized controlled trial with multiple primary outcomes.GeroScience · 2024Trial
- A novel clinical biomarker-based Physiology Healthy Aging Index and risk of all-cause and cause-specific mortality: A 20-year prospective cohort study.GeroScience · 2026Article
- Association between long-term healthy aging trajectories and all-cause mortality among middle-aged and older adults.Archives of public health = Archives belges de sante publique · 2025Article
- Metabolomic Pathways of Inflammation and Mitochondrial Dysfunction Are Related to Worsening Healthy Aging Index and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Combined impact of neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and cognitive function on all-cause mortality in older adults: a population-based study.Lipids in health and disease · 2025Article
- The association of biological age and its trajectory with incident heart failure: a cohort study from China.Frontiers in cardiovascular medicine · 2025Article
- Association of a healthy ageing index with health-related outcomes in a multi-ethnic cohort from Singapore.BMC geriatrics · 2024Article
- Associations of healthy aging index and all-cause and cause-specific mortality: a prospective cohort study of UK Biobank participants.GeroScience · 2024Article
- Measuring healthy ageing: current and future tools.Biogerontology · 2023Review
- A holistic model of health inequalities for health policy and state administration: a case study in the regions of the Czech Republic.International journal for equity in health · 2023Article
- Associations of Modified Healthy Aging Index With Major Adverse Cardiac Events, Major Coronary Events, and Ischemic Heart Disease.Journal of the American Heart Association · 2023Article
- Predictors of healthy physiological aging across generations in a 30-year population-based cohort study: the Doetinchem Cohort Study.BMC geriatrics · 2023Article
- Assessing Healthy Aging Score and Its Association With All-Cause Mortality: Findings From the China Health and Retirement Longitudinal Study.Innovation in aging · 2023Article
- The association between healthy aging index and trajectories of disability: a population-based cohort study.Aging clinical and experimental research · 2022Article
- Article
- The change and correlates of healthy ageing among Chinese older adults: findings from the China health and retirement longitudinal study.BMC geriatrics · 2021Article
- Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Review
- Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways.Aging and disease · 2019Review
- A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.GeroScience · 2018Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundBaseline scores on a Healthy Aging Index (HAI), including five key physiologic domains, strongly predict health outcomes. This study aimed to characterize 9-year changes in a HAI and explore their relationship to subsequent mortality.
methodsData are from the Health, Aging, and Body Composition study of well-functioning adults aged 70-79 years. A HAI, which ranges from 0 to 10, was constructed at years 1 and 10 of the study including systolic blood pressure, forced expiratory volume, digit symbol substitution test, cystatin C, and fasting glucose. The relationships between the HAI at years 1 and 10 and the change between years and subsequent mortality until year 17 were estimated from Cox proportional hazards models.
resultsTwo thousand two hundred sixty-four participants had complete data on a HAI at year 1, of these 1,122 had complete data at year 10. HAI scores tended to increase (i.e. get worse) over 9-year follow-up, from (mean [SD]) 4.3 (2.1) to 5.7 (2.1); mean within-person change 1.5 (1.6). After multivariable adjustment, HAI score was related to mortality from year 1 (hazard ratio [95% confidence interval] = 1.17 [1.13-1.21] per unit) and year 10 (1.20 [1.14-1.27] per unit). The change between years was also related to mortality (1.08 [1.02-1.15] per unit change).
conclusionsHAI scores tended to increase with advancing age and stratified mortality rates among participants remaining at year 10. The HAI may prove useful to understand changes in health with aging.
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