Evidence map›Paper›PMID 29733204›Full record

ArticleBiochemistry2018

Molecular Mechanism for Folding Cooperativity of Functional RNAs in Living Organisms.

Kathleen A Leamy, Neela H Yennawar, Philip C Bevilacqua

Abstract read
In one paragraph

Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Single-nucleotide control of tRNA folding cooperativity under near-cellular conditions.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kathleen A LeamyDepartment of Chemistry , Pennsylvania State University , University Park , Pennsylvania 16802 , United States.
Neela H YennawarHuck Institutes of the Life Sciences , Pennsylvania State University , University Park , Pennsylvania 16802 , United States.
Philip C BevilacquaDepartment of Chemistry , Pennsylvania State University , University Park , Pennsylvania 16802 , United States.ORCID 0000-0001-8074-3434
Pennsylvania State University · US

Funding

Overall (pp. 40-62)P41GM103485 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2012 to 2018
$15.5M
RNA Folding and Adaptation in a Cellular ContextR01GM110237 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BEVILACQUA, PHILIP C · 2014 to 2017
$1.1M
NIGMS NIH HHS P41 GM103485NIGMS NIH HHS R01 GM110237
6 · The paper itself

Abstract

A diverse set of organisms has adapted to live under extreme conditions. The molecular origin of the stability is unclear, however. It is not known whether the adaptation of functional RNAs, which have intricate tertiary structures, arises from strengthening of tertiary or secondary structure. Herein we evaluate effects of sequence changes on the thermostability of tRNA

Indexed as

Evolution, MolecularRNA FoldingBase PairingConserved SequenceHot TemperatureNucleic Acid ConformationRNA StabilityRNA, Transfer, PheRNA, Transfer, Phe

Identifiers

PMID29733204
PMCPMC6726375
OpenAlexW2802049840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.