ArticleThe International journal of risk & safety in medicine2018
Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases.
Article in The International journal of risk & safety in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03879369 (Sexual Dysfunction in Female Patients With Adult Acne Vulgaris), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sexual Dysfunction in Female Patients With Adult Acne Vulgaris
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Could isotretinoin be a new therapeutic frontier for male infertility? A systematic review and meta-analysis.International urology and nephrology · 2026Pooled it
- The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review.Human reproduction update · 2020Pooled it
- Long-term harms from previous use of selective serotonin reuptake inhibitors: A systematic review.The International journal of risk & safety in medicine · 2019Pooled it
- Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications.Frontiers in neuroendocrinology · 2026Review
- Insights into the peripheral nature of persistent sexual dysfunction associated with post-finasteride, post-SSRI and post-accutane syndromes: lessons learned from a case study.International urology and nephrology · 2025Article
- Frequency of self-reported persistent post-treatment genital hypoesthesia among past antidepressant users: a cross-sectional survey of sexual and gender minority youth in Canada and the US.Social psychiatry and psychiatric epidemiology · 2025Article
- The post-finasteride syndrome: possible etiological mechanisms and symptoms.International journal of impotence research · 2025Review
- Post-SSRI sexual dysfunction: barriers to quantifying incidence and prevalence.Epidemiology and psychiatric sciences · 2024Review
- Isotretinoin exposure does not appear to be associated with risk of adverse male sexual health outcomes in acne patients.International journal of dermatology · 2024Article
- A clinical guide to rare male sexual disorders.Nature reviews. Urology · 2024Review
- Clinical characterisation of women with persistent genital arousal disorder: the iPGAD-study.Scientific reports · 2023Article
- Patient reporting of sexual adverse events on an online platform for medication experiences.British journal of clinical pharmacology · 2022Article
- Exploring the link between eating disorders and persistent genital arousal disorder/genito-pelvic dysesthesia: first description and a systematic review of the literature.Journal of eating disorders · 2022Review
- Medications Most Commonly Associated With Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database.Sexual medicine · 2022Article
- Cutting the First Turf to Heal Post-SSRI Sexual Dysfunction: A Male Retrospective Cohort Study.Medicines (Basel, Switzerland) · 2022Article
- Individualized identification of sexual dysfunction of psychiatric patients with machine-learning.Scientific reports · 2022Article
- Diagnostic criteria for enduring sexual dysfunction after treatment with antidepressants, finasteride and isotretinoin.The International journal of risk & safety in medicine · 2022Article
- Simultaneous Quantification of Four Ginsenosides in Rat Plasma and Its Application to a Comparative Pharmacokinetic Study in Normal and Depression Rats Using UHPLC-MS/MS.Journal of analytical methods in chemistry · 2021Article
- Post-finasteride syndrome: An emerging clinical problem.Neurobiology of stress · 2020Article
- Antidepressants and sexual dysfunction: a history.Journal of the Royal Society of Medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate clinical reports of post-SSRI sexual dysfunction (PSSD), post-finasteride syndrome (PFS) and enduring sexual dysfunction following isotretinoin.
methodsData from RxISK.org, a global adverse event reporting website, have been used to establish the clinical features, demographic details and clinical trajectories of syndromes of persistent sexual difficulties following three superficially different treatment modalities.RESULTSWe report on 300 cases of enduring sexual dysfunction from 37 countries following 14 different drugs comprised of serotonin reuptake inhibiting antidepressants, 5α-reductase inhibitors and isotretinoin. While reports of certain issues were unique to the antidepressants, such as the onset of premature ejaculation and persistent genital arousal disorder (PGAD), there was also a significant overlap in symptom profile between the drug groups, with common features including genital anaesthesia, pleasureless or weak orgasm, loss of libido and impotence. Secondary consequences included relationship breakdown and impaired quality of life.CONCLUSIONSThese data point to a legacy syndrome or syndromes comprising a range of disturbances to sexual function. More detailed studies will require developments in coding systems that recognise the condition(s). Further exploration of these tardive sexual syndromes may yield greater understanding of tardive syndromes in general.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.