ArticleJournal of the Endocrine Society2018
Type 2 Diabetes: When Does It Start?
Article in Journal of the Endocrine Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Effects of Ketone Ester Supplementation on Cognition and Appetite in Individuals with and Without Metabolic syndrome: A Randomized Trial.Journal of dietary supplements · 2025Trial
- Clinical characteristics, disease course, and clinical subgroups of young adults with type 2 diabetes.Journal of the Endocrine Society · 2026Article
- Breakpoint-resolved balanced t(2;12)(q35;q24.31) disruptingMetabolism open · 2026Article
- Evaluation of Serum Antioxidant Activity in Type 2 Diabetes and Prediabetes: Links with Nutritional and Anthropometric Factors-Preliminary Studies.Current issues in molecular biology · 2025Article
- Evaluating the role of alpha cell dysregulation in the progression to type 2 diabetes using mathematical simulations.Diabetologia · 2025Article
- Prediction of Pancreatic Cancer Risk in Patients with New-Onset Diabetes.Visceral medicine · 2025Review
- Prevalence and underdiagnosis of diabetes mellitus in a food insecure population.Scientific reports · 2025Article
- Intermittent fasting regulates gut microbiota and serum metabolome profiles in middle-aged mice fed high-fat diet.Nutrition & metabolism · 2025Article
- Article
- Association between SPISE and NAFLD in patients with type 2 diabetes.Frontiers in medicine · 2025Article
- Warning Signs: Occult Diabetes and Dysglycemia in the Hand Surgery Patient Population.Hand (New York, N.Y.) · 2024Article
- SPISE INDEX (Single point insulin sensitivity estimator): indicator of insulin resistance in children and adolescents with overweight and obesity.Frontiers in endocrinology · 2024Article
- Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy.The Cochrane database of systematic reviews · 2023Review
- Single Point Insulin Sensitivity Estimator (SPISE) As a Prognostic Marker for Emerging Dysglycemia in Children with Overweight or Obesity.Metabolites · 2023Article
- Time to Diagnosis and Treatment of Diabetes Mellitus among Korean Adults with Hyperglycemia: Using a Community-Based Cohort Study.International journal of environmental research and public health · 2022Article
- Hepatic Steatosis and High-Normal Fasting Glucose as Risk Factors for Incident Prediabetes.Journal of the Endocrine Society · 2022Article
- Single Point Insulin Sensitivity Estimator for predicting type 2 diabetes mellitus in obese adolescents.Annals of pediatric endocrinology & metabolism · 2022Article
- The Theory of Hyperlipidemic Memory of Type 1 Diabetes.Frontiers in endocrinology · 2022Article
- Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease.Frontiers in endocrinology · 2022Article
- The single-point insulin sensitivity estimator (SPISE) index is a strong predictor of abnormal glucose metabolism in overweight/obese children: a long-term follow-up study.Journal of endocrinological investigation · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to clarify the onset of diabetes.
designData from 27,392 nondiabetic health examinees were retrospectively analyzed for a mean of 5.3 years. Trajectories of fasting plasma glucose (FPG), body mass index (BMI), and the single point insulin sensitivity (Si) estimator (SPISE), an index of Si, 10 years before diagnosis of prediabetes (PDM; n = 4781) or diabetes (n = 1061) were separately assessed by a mixed effects model. Diabetes and PDM were diagnosed by the American Diabetes Association definition on the basis of FPG and glycosylated hemoglobin A1c values.
resultsIn individuals who developed diabetes, mean FPG and BMI were significantly higher (
conclusionsFPG was significantly elevated in those who developed diabetes at least 10 years before diagnosis of diabetes, and this was also the case in those who developed PDM. Glucose dysregulation precedes diagnosis of diabetes at least for 20 years.
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