ArticleACS omega2018
Design, Synthesis, and Biological Evaluations of Asymmetric Bow-Tie PAMAM Dendrimer-Based Conjugates for Tumor-Targeted Drug Delivery.
Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Core-Tunable Dendritic Polymer: A Folate-Guided Theranostic Nanoplatform for Drug Delivery Applications.ACS omega · 2024Article
- Janus Dendrimers as Nanocarriers of Ibuprofen, Chlorambucil and their Anticancer Activity.Pharmaceutical nanotechnology · 2024Article
- Branched Poly(International journal of molecular sciences · 2022Article
- Strategies for the drug discovery and development of taxane anticancer therapeutics.Expert opinion on drug discovery · 2022Review
- Design, synthesis and SAR study of Fluorine-containing 3rd-generation taxoids.Bioorganic chemistry · 2022Article
- Nanoarchitectures for efficient IgE cross-linking on effector cells to study amoxicillin allergy.Allergy · 2021Article
- Optimization and computational studies evaluating molecular dynamics of EDA cored polymeric dendrimer.Scientific reports · 2020Article
- Rational design and latest advances of codelivery systems for cancer therapy.Materials today. Bio · 2020Review
- Pseudo-branched polyester copolymer: an efficient drug delivery system to treat cancer.Biomaterials science · 2020Article
- Design, synthesis and SAR study of 3rd-generation taxoids bearing 3-CHBioorganic chemistry · 2020Article
- Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications.Materials (Basel, Switzerland) · 2019Review
- Crystallization and Temperature Driven Morphological Evolution of Bio-based Polyethylene Glycol-acrylic Rosin Polymer.Polymers · 2019Article
- Design, Synthesis, and Characterization of Fully Zwitterionic, Functionalized Dendrimers.ACS omega · 2019Article
- Polyamidoamine Dendrimers for Enhanced Solubility of Small Molecules and Other Desirable Properties for Site Specific Delivery: Insights from Experimental and Computational Studies.Molecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A unique asymmetric bow-tie poly(amidoamine) (PAMAM) dendrimer (ABTD) scaffold was designed and developed as a well-defined macromolecular carrier for tumor-targeted drug delivery. The ABTD scaffold in this study consists of a G3-half-dendron (G3-HD) unit and a G1-half-dendron (G1-HD) unit, bearing thiol moiety in each unit and a bis(maleimide) linker unit, which undergo sequential thiol-maleimide coupling to assemble the scaffold. This assembly methodology is applicable to all other combinations of different generations of PAMAM dendrimers. In the prototype ABTD in this study, 16 biotin moieties were tethered to the G3-HD unit and 4 payloads (new-generation taxoid) to the G1-HD via a self-immolative linker to form an ABTD-tumor-targeting conjugate (ABTD-TTC-1). Two other ABTD-TTCs were synthesized, wherein the G1-HD unit was tethered to a fluorescence-labeled taxoid or to a fluorescent probe. These three ABTD-TTCs were constructed by using a common key ABTD
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Registered trials
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