Evidence map›Paper›PMID 29732439›Full record

ArticleJACC. Basic to translational science2018

Rad GTPase deletion attenuates post-ischemic cardiac dysfunction and remodeling.

Janet R Manning, Lakshman Chelvarajan, Bryana M Levitan, Catherine N Withers, Prabhakara R Nagareddy, Christopher M Haggerty, Brandon K Fornwalt, Erhe Gao, Himi Tripathi, Ahmed Abdel-Latif and 2 more

Open access · goldAbstract read
In one paragraph

Article in JACC. Basic to translational science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Rad-mediated inhibition of CaThe Journal of physiology · 2024
    Article
  4. Review
  5. Sympathetic Nervous System Regulation of Cardiac Calcium Channels.Handbook of experimental pharmacology · 2023
    Article
  6. Rad-GTPase contributes to heart rate via L-type calcium channel regulation.Journal of molecular and cellular cardiology · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Janet R ManningDepartment of Physiology, University of Kentucky, Lexington KY.
Lakshman ChelvarajanSaha Cardiovascular Research Center, Department of Medicine, University of Kentucky, Lexington, KY.
Bryana M LevitanDepartment of Physiology, University of Kentucky, Lexington KY.
Catherine N WithersDepartment of Biochemistry, University of Kentucky, Lexington KY.
Prabhakara R NagareddyDepartment of Nutrition Sciences, University of Alabama, Birmingham AL.
Christopher M HaggertySaha Cardiovascular Research Center, Department of Medicine, University of Kentucky, Lexington, KY.
Brandon K FornwaltSaha Cardiovascular Research Center, Department of Medicine, University of Kentucky, Lexington, KY.
Erhe GaoDepartment of Physiology, University of Kentucky, Lexington KY.
Himi TripathiSaha Cardiovascular Research Center, Department of Medicine, University of Kentucky, Lexington, KY.
Ahmed Abdel-LatifSaha Cardiovascular Research Center, Department of Medicine, University of Kentucky, Lexington, KY.
Douglas A AndresDepartment of Biochemistry, University of Kentucky, Lexington KY.
Jonathan SatinDepartment of Physiology, University of Kentucky, Lexington KY.
University of Kentucky · USGeisinger Medical Center · USTemple University · USUniversity of Alabama at Birmingham · US

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2012 to 2017
$13.7M
Mechanisms of Long-term Cardiac Ion Channel RegulationR01HL074091 · NHLBI · UNIVERSITY OF KENTUCKY · PI SATIN, JONATHAN · 2003 to 2013
$3.3M
Regulation of Calcium Channel Function by the Rem GTPaseR01HL072936 · NHLBI · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN, SATIN, JONATHAN · 2003 to 2013
$3.0M
Monomeric G-proteins and Cardioprotection from Heart FailureR01HL131782 · NHLBI · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN, SATIN, JONATHAN · 2017 to 2019
$1.6M
Monomeric G-proteins and Cardioprotection from Heart FailureR56HL131782 · NHLBI · UNIVERSITY OF KENTUCKY · PI ANDRES, DOUGLAS ALLEN, SATIN, JONATHAN · 2016 to 2016
$525k
Role of Bioactive Lipids in Stem Cell Mobilization and Homing in Cardiac IschemiaR56HL124266 · NHLBI · UNIVERSITY OF KENTUCKY · PI ABDEL-LATIF, AHMED · 2014 to 2014
$375k
Prevention of heart failure and remodeling through calcium channel modulationF32HL126300 · NHLBI · UNIVERSITY OF KENTUCKY · PI MANNING, JANET R · 2015 to 2016
$112k
American Heart Association-American Stroke Association 14POST20460224NHLBI NIH HHS F32 HL126300NHLBI NIH HHS R01 HL072936NHLBI NIH HHS R01 HL074091NHLBI NIH HHS R01 HL131782NHLBI NIH HHS R56 HL124266NHLBI NIH HHS R56 HL131782NIGMS NIH HHS P20 GM103527
6 · The paper itself

Abstract

The protein Rad interacts with the LTCC to modulate trigger Ca

Identifiers

PMID29732439
PMCPMC5931223
OpenAlexW2791707705

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.