ArticleScience advances2018
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 351 citations in OpenAlex.
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- Biosynthesis of long-chain omega-3 fatty acids by the nestlings of a generalist seabird.The Journal of experimental biology · 2025Article
- Investigating the potential of dietary iron supplementation to enhance long-chain polyunsaturated fatty acid biosynthesis in Hediste diversicolor.Scientific reports · 2025Article
- Freshwater-adapted polychaetes exhibit a complete enzymatic machinery for synthesizing long-chain polyunsaturated fatty acids.Open biology · 2025Article
- Selective nutrient incorporation may underestimate heterotrophy of a mixotrophic reef-building coral.Communications biology · 2025Article
- Effect of Organic Plant Ingredients on the Growth Performance of European Sea Bass (Animals : an open access journal from MDPI · 2025Article
- Contact- and Water-Mediated Interactions With an Allelopathic Macroalga Drive Distinct Coral Microbiome and Metabolome.Environmental microbiology · 2025Article
- Recent Knowledge in the Application ofAntibiotics (Basel, Switzerland) · 2025Review
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- Photobiota of the Tropical Red Sea: Fatty Acid Profile Analysis and Nutritional Quality Assessments.Molecules (Basel, Switzerland) · 2025Article
- Production, Transport, Fate and Effects of Lipids in the Marine Environment.Marine drugs · 2025Review
- Enzymes enabling the biosynthesis of various COpen biology · 2025Article
- Nutrition, production, and processing of virgin omega-3 polyunsaturated fatty acids in dairy: An integrative review.Heliyon · 2024Review
- High-resolution chromosome-level genome of Scylla paramamosain provides molecular insights into adaptive evolution in crabs.BMC biology · 2024Article
- Modulation of fatty acid profiles and turnover dynamics in jellyfish polyps through copepod diets: Insights into trophic interactions and nutrient flux.Ecology and evolution · 2024Article
- Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desaturases. ωx desaturases have also been described in a small number of invertebrate animals, but their precise distribution has not been systematically explored. This study identifies 121 ωx desaturase sequences from 80 species within the Cnidaria, Rotifera, Mollusca, Annelida, and Arthropoda. Horizontal gene transfer has contributed to this hitherto unknown widespread distribution. Functional characterization of animal ωx desaturases provides evidence that multiple invertebrates have the ability to produce ω3 PUFA de novo and further biosynthesize ω3 long-chain PUFA. This finding represents a fundamental revision in our understanding of ω3 long-chain PUFA production in global food webs, by revealing that numerous widespread and abundant invertebrates have the endogenous capacity to make significant contributions beyond that coming from marine microbes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.