ArticleBladder cancer (Amsterdam, Netherlands)2018
Bladder Cancer Genetic Susceptibility. A Systematic Review.
Article in Bladder cancer (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gene network profiling in muscle-invasive bladder cancer: A systematic review and meta-analysis.Urologic oncology · 2022Pooled it
- Urea Transporters in Cancer: Emerging Roles and Their Clinical Implications.Biomedicines · 2025Review
- Association ofSouth Asian journal of cancer · 2025Article
- Gene and pathway analysis of genome-wide genetic associations of bladder cancer.Current urology · 2025Article
- Global Trends in Urological Evidence Synthesis: A Bibliometric Analysis of Systematic Reviews and Meta-analyses.Medical journal of the Islamic Republic of Iran · 2025Review
- Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression.Scientific reports · 2024Article
- A Case-Only Genome-Wide Interaction Study of Smoking and Bladder Cancer Risk: Results from the COBLAnCE Cohort.Cancers · 2023Article
- Global trends in the epidemiology of bladder cancer: challenges for public health and clinical practice.Nature reviews. Clinical oncology · 2023Review
- Genetic Polymorphisms Involved in Bladder Cancer: A Global Review.Oncology reviews · 2023Article
- Bladder cancer course, four genetic high-risk variants, and histopathological findings.EXCLI journal · 2023Article
- Interaction between blood pressure and genetic risk score for bladder cancer, and risk of urothelial carcinoma in men.Scientific reports · 2022Article
- Genetic susceptibility of bladder cancer in the Lebanese population.BMC medical genomics · 2022Review
- Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck.International journal of cancer · 2022Article
- The interaction between smoking and bladder cancer genetic variants on urothelial cancer risk by disease aggressiveness.Cancer medicine · 2022Article
- DNA Repair Gene Polymorphisms and Susceptibility to Urothelial Carcinoma in a Southeastern European Population.Current oncology (Toronto, Ont.) · 2021Article
- Identification of Genetic Risk Factors for Familial Urinary Bladder Cancer: An Exome Sequencing Study.JCO precision oncology · 2021Article
- How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers.Frontiers in oncology · 2021Review
- Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors.Sensors (Basel, Switzerland) · 2020Article
- TP63 isoform expression is linked with distinct clinical outcomes in cancer.EBioMedicine · 2020Article
- Computational Prediction of Probable Single Nucleotide Polymorphism-Cancer Relationships.Cancer informatics · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe variant/gene candidate approach to explore bladder cancer (BC) genetic susceptibility has been applied in many studies with significant findings reported. However, results are not always conclusive due to the lack of replication by subsequent studies.
objectivesTo identify all epidemiological investigations on the genetic associations with BC risk, to quantify the likely magnitude of the associations by applying metaanalysis methodology and to assess whether there is a potential for publication/reporting bias.
methodsTo address our aims, we have catalogued all genetic association studies published in the field of BC risk since 2000. Furthermore, we metaanalysed all polymorphisms with data available from at least three independent case-control studies with subjects of Caucasian origin analyzed under the same mode of inheritance.
resultsThe characterization of the genetic susceptibility of BC is composed of 28 variants, GWAS contributing most of them. Most of the significant variants associated with BC risk are located in genes belonging to chemical carcinogenesis, DNA repair, and cell cycle pathways. Causal relationship was also provided by functional analysis for
conclusionsGenetic susceptibility of BC is still poorly defined, with GWAS contributing most of the strongest evidence. The systematic review did not provide evidence of further genetic associations. The potential public health translation of the existing knowledge on genetic susceptibility on BC is still limited.
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