ArticleOpen forum infectious diseases2018
Antimicrobial Agent Shortages: The New Norm for Infectious Diseases Physicians.
Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05090475 (Evaluating Hospital Educator-led Academic Detailing on Improving Antibiotic Prescribing in Primary Healthcare), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Hospital Educator-led Academic Detailing on Improving Antibiotic Prescribing in Primary Healthcare: a Feasibility Study
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial.BMC pulmonary medicine · 2020Trial
- The Impact of a Nationwide Blood Culture Bottle Shortage in 2024 on Healthcare Facilities in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Article
- Addressing Drug Shortages at Mediclinic Parkview Hospital: A Five-Year Study of Challenges, Impact, and Strategies.Cureus · 2024Article
- The impact of meropenem shortage and post-prescription review and feedback on broad-spectrum antimicrobial use: An interrupted time-series analysis.Infection prevention in practice · 2024Article
- A pharmaceutical policy accident: collision of shareholder capitalism and Chinese state capitalism driving the shortage of an essential antibiotic.Journal of pharmaceutical policy and practice · 2024Article
- Consecutive antibiotic shortages highlight discrepancies between microbiology and prescribing practices for intra-abdominal infections.Antimicrobial agents and chemotherapy · 2023Article
- Comparative Effectiveness of Ampicillin/Sulbactam versus Cefazolin as Targeted Therapy for Bacteremia Caused by Beta-Lactamase-Producing Methicillin-SensitiveAntibiotics (Basel, Switzerland) · 2022Article
- Effects of the cefazolin shortage on the sales, cost, and appropriate use of other antimicrobials.BMC health services research · 2021Article
- Observational
- Shortages Without Frontiers: Antimicrobial Drug and Vaccine Shortages Impact Far Beyond the Individual!Frontiers in medicine · 2021Article
- Drug Shortage: Causes, Impact, and Mitigation Strategies.Frontiers in pharmacology · 2021Review
- Occurrence of Hyperbilirubinemia in Neonates Given a Short-term Course of Ceftriaxone versus Cefotaxime for Sepsis.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- Evaluation of a hybrid antimicrobial restriction process at a large academic medical center.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2021Article
- Results of EAHP's 2019 Medicines Shortages Survey.European journal of hospital pharmacy : science and practice · 2020Article
- Prospective evaluating the appropriate use of piperacillin /tazobactam in cardiac center of a tertiary care hospital.Journal of cardiothoracic surgery · 2020Article
- Risks in Antibiotic Substitution Following Medicine Shortage: A Health-Care Failure Mode and Effect Analysis of Six European Hospitals.Frontiers in medicine · 2020Article
- Availability and Use of Therapeutic Interchange Policies in Managing Antimicrobial Shortages among South African Public Sector Hospitals; Findings and Implications.Antibiotics (Basel, Switzerland) · 2019Article
- Observational Study of Antibiotic Usage at the Children's Clinical University Hospital in Riga, Latvia.Medicina (Kaunas, Lithuania) · 2018Observational
- Hospital pharmacy acquisition of nonstocked antimicrobials-current processes and areas for improvement.Journal of the American Pharmacists Association : JAPhAArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIn 2012, the US Food and Drug Administration (FDA) required drug manufacturers to give advance notice of impending drug shortages. A survey of infectious diseases (ID) physicians was undertaken to determine the impact of this requirement and to follow-up on prior perceptions of ID physicians on shortages of antimicrobial agents.
methodsWe used a web-based survey of ID physician members of the Emerging Infections Network in 2016.
resultsOf the 701 of 1597 members (44%) who responded, 70% reported the need to modify their antimicrobial choice because of a shortage in the prior 2 years. A majority (73%) reported the shortages affected patient care or outcomes by the use of broader-spectrum (75%), more costly (58%), less effective second-line (45%), or more toxic agents (37%). The most commonly reported antimicrobials in short supply were piperacillin-tazobactam, ampicillin-sulbactam, meropenem, cefotaxime, and cefepime. Respondents learned of shortages from hospital notification, from a colleague, contact from pharmacy after ordering the agent in short supply, or FDA or other website. The antimicrobial stewardship programs (ASPs) of a majority (83%) of respondents' institutions had developed approaches to deal with shortages. Although 71% indicated that communications were sufficient, most (87%) did not perceive any improvement in communications about shortages since the 2012 FDA requirement.
conclusionsThe persistence of antimicrobial agent shortages reported by ID physicians is disturbing as is the resulting need to use broader-spectrum or more toxic agents. The prominent role of ASPs in helping to deal with shortages, effective communication channels, and the lack of perceived improvement in FDA's communication strategy merit further consideration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.