Evidence map›Paper›PMID 29732362›Full record

ArticleCanadian journal of gastroenterology & hepatology2018

Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study.

Umberto Vespasiani-Gentilucci, Chiara Dell'Unto, Antonio De Vincentis, Andrea Baiocchini, Marco Delle Monache, Roberto Cecere, Adriano Maria Pellicelli, Valerio Giannelli, Simone Carotti, Giovanni Galati and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of gastroenterology & hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Global Epidemiology and Implications ofJournal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Umberto Vespasiani-GentilucciInternal Medicine, Geriatrics, and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.ORCID 0000-0002-1138-1967
Chiara Dell'UntoInternal Medicine, Geriatrics, and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
Antonio De VincentisInternal Medicine, Geriatrics, and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
Andrea BaiocchiniLaboratory of Pathology of The National Institute for Infectious Diseases, Lazzaro Spallanzani, Rome, Italy.
Marco Delle MonacheHepatology Outpatient Clinic, Colleferro Hospital, Rome, Italy.
Roberto CecereHepatology Outpatient Clinic, Colleferro Hospital, Rome, Italy.
Adriano Maria PellicelliLiver Disease Unit, San Camillo-Forlanini Hospital, Rome, Italy.
Valerio GiannelliLiver Disease Unit, San Camillo-Forlanini Hospital, Rome, Italy.
Simone CarottiLaboratory of Microscopic and Ultrastructural Anatomy, CIR, University Campus Bio-Medico, Rome, Italy.
Giovanni GalatiInternal Medicine, Geriatrics, and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
Paolo GalloInternal Medicine, Geriatrics, and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
Francesco ValentiniInternal Medicine, Geriatrics, and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
Franca Del NonnoLaboratory of Pathology of The National Institute for Infectious Diseases, Lazzaro Spallanzani, Rome, Italy.
Davide RosatiUniversity La Sapienza of Rome, Rome, Italy.
Sergio MoriniLaboratory of Microscopic and Ultrastructural Anatomy, CIR, University Campus Bio-Medico, Rome, Italy.
Raffaele Antonelli-IncalziInternal Medicine, Geriatrics, and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.
Antonio PicardiInternal Medicine, Geriatrics, and Hepatology Unit, University Campus Bio-Medico, Rome, Italy.ORCID 0000-0002-0230-218X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Aims: Identifying NAFLD patients at risk of progression is crucial to orient medical care and resources. We aimed to verify if the effects determined by different single nucleotide polymorphisms (SNPs) could add up to multiply the risk of NAFLD and NASH-cirrhosis. Methods: Three study populations, that is, patients diagnosed with NASH-cirrhosis or with noncirrhotic NAFLD and healthy controls, were enrolled. PNPLA3 rs738409, TM6SF2 rs58542926, KLF6 rs3750861, SOD2 rs4880, and LPIN1 rs13412852 were genotyped. Results: One hundred and seven NASH-cirrhotics, 93 noncirrhotic NAFLD, and 90 controls were enrolled. At least one difference in allele frequency between groups was significant, or nearly significant, for the PNPLA3, TM6SF2, and KLF6 variants ( Conclusions: The effects determined by disease-associated variants at different

Indexed as

AcyltransferasesAdultAgedCase-Control StudiesDisease ProgressionGene FrequencyGenetic LociGenotypeHumansKruppel-Like Factor 6LipaseLiver CirrhosisMembrane ProteinsMiddle AgedNon-alcoholic Fatty Liver DiseasePhosphatidate PhosphataseAcyltransferasesKLF6 protein, humanKruppel-Like Factor 6LipaseLPIN1 protein, humanMembrane ProteinsPhosphatidate PhosphatasePhospholipases A2, Calcium-IndependentPNPLA3 protein, humanSuperoxide DismutaseSuperoxide Dismutase 2TM6SF2 protein, human

Identifiers

PMID29732362
PMCPMC5872672

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.