ArticleApplications in plant sciences2018
A protocol for high-throughput, untargeted forest community metabolomics using mass spectrometry molecular networks.
Article in Applications in plant sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Environmental drivers of metabolomic profiles within and between cryptic lineages of Montastraea cavernosa, the great star coral.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Nectar metabolomes contribute to pollination syndromes.The New phytologist · 2025Article
- Statistical analysis of feature-based molecular networking results from non-targeted metabolomics data.Nature protocols · 2025Article
- Tree phytochemical diversity and herbivory are higher in the tropics.Nature ecology & evolution · 2024Article
- Screening of leaf extraction and storage conditions for eco-metabolomics studies.Plant direct · 2024Article
- The Impact of the Culture Regime on the Metabolome and Anti-Phytopathogenic Activity of Marine Fungal Co-Cultures.Marine drugs · 2024Article
- Leaf volatile and nonvolatile metabolites show different levels of specificity in response to herbivory.Ecology and evolution · 2023Article
- [A novel method for efficient screening and annotation of important pathway-associated metabolites based on the modified metabolome and probe molecules].Se pu = Chinese journal of chromatography · 2022Article
- Chemical novelty facilitates herbivore resistance and biological invasions in some introduced plant species.Ecology and evolution · 2020Article
- Evaluation of an untargeted nano-liquid chromatography-mass spectrometry approach to expand coverage of low molecular weight dissolved organic matter in Arctic soil.Scientific reports · 2019Article
- Article
- A protocol for high-throughput, untargeted forest community metabolomics using mass spectrometry molecular networks.Applications in plant sciences · 2018Article
- Practical considerations for plant phylogenomics.Applications in plant sciences · 2018Review
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
premise of the studyWe describe a field collection, sample processing, and ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) instrumental and bioinformatics method developed for untargeted metabolomics of plant tissue and suitable for molecular networking applications. METHODS AND
resultsA total of 613 leaf samples from 204 tree species was collected in the field and analyzed using UHPLC-MS/MS. Matching of molecular fragmentation spectra generated over 125,000 consensus spectra representing unique molecular structures, 26,410 of which were linked to at least one structurally similar compound.
conclusionsOur workflow is able to generate molecular networks of hundreds of thousands of compounds representing broad classes of plant secondary chemistry and a wide range of molecular masses, from 100 to 2500 daltons, making possible large-scale comparative metabolomics, as well as studies of chemical community ecology and macroevolution in plants.
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