Evidence map›Paper›PMID 29732096›Full record

ArticleChemical science2018

Nanobubble-embedded inorganic 808 nm excited upconversion nanocomposites for tumor multiple imaging and treatment.

Ming-Hsien Chan, Yu-Ting Pan, Yung-Chieh Chan, Michael Hsiao, Chung-Hsuan Chen, Lingdong Sun, Ru-Shi Liu

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Review
  3. Bioimaging with Upconversion Nanoparticles.Advanced photonics research · 2022
    Article
  4. Review
  5. Dye Sensitization for Ultraviolet Upconversion Enhancement.Nanomaterials (Basel, Switzerland) · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Ming-Hsien ChanDepartment of Chemistry , National Taiwan University , Taipei 106 , Taiwan . Email: rsliu@ntu.edu.tw.
Yu-Ting PanDepartment of Chemistry , National Taiwan University , Taipei 106 , Taiwan . Email: rsliu@ntu.edu.tw.
Yung-Chieh ChanGenomics Research Center , Academia Sinica , Taipei 115 , Taiwan . Email: mhsiao@gate.sinica.edu.tw.
Michael HsiaoGenomics Research Center , Academia Sinica , Taipei 115 , Taiwan . Email: mhsiao@gate.sinica.edu.tw.
Chung-Hsuan ChenGenomics Research Center , Academia Sinica , Taipei 115 , Taiwan . Email: mhsiao@gate.sinica.edu.tw.
Lingdong SunBeijing National Laboratory for Molecular Sciences , State Key Laboratory of Rare Earth Materials Chemistry and Applications , PKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry , College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , China.
Ru-Shi LiuDepartment of Chemistry , National Taiwan University , Taipei 106 , Taiwan . Email: rsliu@ntu.edu.tw.ORCID 0000-0002-1291-9052
Genomics Research Center, Academia Sinica · TWNational Taiwan University · TWKaohsiung Medical University · TWNational Taipei University of Technology · TWPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contrast reagents for ultrasound imaging are widely used in clinical medical diagnosis because ultrasound resolution is limited. Contrast agents must be utilized to enhance the image resolution. At present, microbubbles (MBs) and nanobubbles (NBs) are the main contrast reagent candidates for improving the signal resolution. Fluorescence upconversion nanoparticles provide high sensitivity and also function as nanocarriers. This can label tumor cells in a specific organ under irradiation of near-infrared (NIR) light. However, despite the use of NIR light, the penetration depth of NIR is only approximately 15 mm. Thus, we combine fluorescence with ultrasonic imaging to achieve the effect of multiple imaging and solve the low penetration depth of fluorescence imaging and the poor resolution of ultrasound imaging. The dual imaging modalities achieved higher resolution or signal to noise ratios. In this study, Nd

Identifiers

PMID29732096
PMCPMC5916109
OpenAlexW2786351716

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.