ArticleChemical science2018
Spironaphthoxazine switchable dyes for biological imaging.
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
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- Super-resolution RESOLFT microscopy of lipid bilayers using a fluorophore-switch dyad.Chemical science · 2020Article
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- A Chalcogen-Bonding Cascade Switch for Planarizable Push-Pull Probes.Angewandte Chemie (International ed. in English) · 2019Article
- A building-block design for enhanced visible-light switching of diarylethenes.Nature communications · 2019Article
- Streptavidin interfacing as a general strategy to localize fluorescent membrane tension probes in cells.Chemical science · 2019Article
- Targeted photoswitchable imaging of intracellular glutathione by a photochromic glycosheet sensor.Beilstein journal of organic chemistry · 2019Article
- Solution and Solid-State Emission Toggling of a Photochromic Hydrazone.Journal of the American Chemical Society · 2018Article
- Super-resolution fluorescence microscopy studies of human immunodeficiency virus.Retrovirology · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
Abstract
Recent developments in super-resolution microscopy have significantly expanded the requirements for switchable dyes, leading to demand for specially designed molecular switches. We report the synthesis and characterization of a spironaphthoxazine photochromic switch (a derivative of palatinate purple) displaying high photoconversion (85-95%) under readily accessible 405 nm light, broad absorption in the visible, and excellent fatigue resistance. The indole substituent on this spironaphthoxazine is twisted out of conjugation with the naphthalene unit, yet it is crucial for activation with visible light. The open colored merocyanine form of the spironaphthoxazine reverts to the closed form with a lifetime of 4.7 s in dichloromethane at 20 °C; this thermal reversion is even faster in more polar solvents. The photochemical quantum yields for ring-opening and ring-closing are approximately 8% and 1%, respectively, in dichloromethane. The ring-opening and ring-closing reactions have been characterized by time-resolved infrared and transient absorption spectroscopies. Ring opening occurs rapidly (
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.