ArticleChemical science2018
Structure and formation of highly luminescent protein-stabilized gold clusters.
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 90 citations in OpenAlex.
- PH-sensitive adriamycin hydrochloride and oxaliplatin dual-loaded microspheres synergistically enhance local injections effect of hepatocellular carcinoma.Materials today. Bio · 2024Article
- Application of gold nanoclusters in fluorescence sensing and biological detection.Analytical and bioanalytical chemistry · 2024Review
- Silver Nanoclusters as Label Free Non-enzymatic Fast Glucose Assay with the Fluorescent Enhancement Signal.Journal of fluorescence · 2024Article
- Fabrication of avidin-stabilized gold nanoclusters with dual emissions and their application in biosensing.Journal of nanobiotechnology · 2022Article
- Evidence of Au(II) and Au(0) States in Bovine Serum Albumin-Au Nanoclusters Revealed by CW-EPR/LEPR and Peculiarities in HR-TEM/STEM Imaging.Nanomaterials (Basel, Switzerland) · 2022Article
- Self-Assembled Metal Nanoclusters: Driving Forces and Structural Correlation with Optical Properties.Nanomaterials (Basel, Switzerland) · 2022Review
- Controllable Synthesis of Bimetallic Nanostructures Using Biogenic Reagents: A Green Perspective.ACS omega · 2021Review
- Isomerization-induced enhancement of luminescence in AuChemical science · 2020Article
- Hard X-ray excited optical luminescence from protein-directed AuRSC advances · 2020Article
- The Effect of Fatty Acids and BSA Purity on Synthesis and Properties of Fluorescent Gold Nanoclusters.Nanomaterials (Basel, Switzerland) · 2020Article
- Gold clusters prevent breast cancer bone metastasis by suppressing tumor-induced osteoclastogenesis.Theranostics · 2020Article
- Ratiometric fluorometric and visual determination of cyanide based on the use of carbon dots and gold nanoclusters.Mikrochimica acta · 2019Article
- Catenane Structures of Homoleptic Thioglycolic Acid-Protected Gold Nanoclusters Evidenced by Ion Mobility-Mass Spectrometry and DFT Calculations.Nanomaterials (Basel, Switzerland) · 2019Article
- Protein-Localized Bright-Red Fluorescent Gold Nanoclusters as Cyanide-Selective Colorimetric and Fluorometric Nanoprobes.ACS omega · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly luminescent gold clusters simultaneously synthesized and stabilized by protein molecules represent a remarkable category of nanoscale materials with promising applications in bionanotechnology as sensors. Nevertheless, the atomic structure and luminescence mechanism of these gold clusters are still unknown after several years of developments. Herein, we report findings on the structure, luminescence and biomolecular self-assembly of gold clusters stabilized by the large globular protein, bovine serum albumin. We highlight the surprising identification of interlocked gold-thiolate rings as the main gold structural unit. Importantly, such gold clusters are in a rigidified state within the protein scaffold, offering an explanation for their highly luminescent character. Combined free-standing cluster synthesis (without protecting protein scaffold) with rigidifying and un-rigidifying experiments, were designed to further verify the luminescence mechanism and gold atomic structure within the protein. Finally, the biomolecular self-assembly process of the protein-stabilized gold clusters was elucidated by time-dependent X-ray absorption spectroscopy measurements and density functional theory calculations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.