ArticleCaspian journal of internal medicine2018
Persistence of immunity to hepatitis B vaccine as infants, 17 years earlier.
Article in Caspian journal of internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Mathematical modeling and simulation of hepatitis B transmission dynamics with passive immunity and control strategies.Heliyon · 2025Article
- Long-Term Hepatitis B Vaccine Immunity in Ethiopian Children That Received a Pentavalent Vaccine Series: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2024Article
- Spontaneous relapse in patients with inactive chronic hepatitis B virus infection.Caspian journal of internal medicine · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn Iran since 1992, hepatitis B vaccination was a part of the national vaccination program. Hepatitis B vaccination is effective in the epidemiology of hepatitis B. The aim of this study was to evaluate the long - term persistence of immunity.
methodsThis cross-sectional analytical study was conducted on children and adolescents aged between 6-18 years in Birjand, who received a three - dose hepatitis B vaccination in accordance with the national immunization program. No students were infected with hepatitis B. Antibody titer higher than10 IU/L was considered positive.
resultsA total of 530 patients (307 boys and 223 girls) were recruited for the study of which 44% had positive antibody titer (≥10 IU / L). The geometric concentration mean (GMCs) of antibody in subjects was 64.9±34.2, HBS antibody titer was positive in 40.4% of the boys and 59.6% of the girls. A significant difference in antibody titers was observed in terms of gender and according to the time elapsed since the last vaccination. Antibody titer in children older than 13 years had passed since their last vaccination and was significantly less than those children younger than thirteen years old had passed since their vaccination logistic regression analysis showed that the only predictive factor of anti-HBS low titer (<10 IU/L) is elapsed time of vaccination.
conclusionsBased on results of this study, hepatitis B vaccine has created a good level of protection in 44% of the adolescents after 17 years.
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