Evidence map›Paper›PMID 29731710›Full record

ArticleFrontiers in cellular neuroscience2018

Neuropathic Pain Causes Pyramidal Neuronal Hyperactivity in the Anterior Cingulate Cortex.

Ruohe Zhao, Hang Zhou, Lianyan Huang, Zhongcong Xie, Jing Wang, Wen-Biao Gan, Guang Yang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 112 citations in OpenAlex.

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  8. Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  18. Distinctive Neurophysiological Signatures of Analgesia after Inflammatory Pain in the ACC of Freely Moving Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ruohe ZhaoLangone Medical Center, Neuroscience Institute, New York University School of Medicine, New York University, New York, NY, United States.
Hang ZhouLangone Medical Center, Neuroscience Institute, New York University School of Medicine, New York University, New York, NY, United States.
Lianyan HuangLangone Medical Center, Neuroscience Institute, New York University School of Medicine, New York University, New York, NY, United States.
Zhongcong XieGeriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Jing WangLangone Medical Center, Neuroscience Institute, New York University School of Medicine, New York University, New York, NY, United States.
Wen-Biao GanLangone Medical Center, Neuroscience Institute, New York University School of Medicine, New York University, New York, NY, United States.
Guang YangLangone Medical Center, Neuroscience Institute, New York University School of Medicine, New York University, New York, NY, United States.
New York University · USNYU Langone Health · USMassachusetts General Hospital · US

Funding

Experience-dependent plasticity of synaptic structure.-Resubmission-1R01NS047325 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAO, MOSES VICTOR · 2004 to 2019
$6.2M
Long-lasting effects of anesthetics on synapse development and plasticityR01GM107469 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI YANG, GUANG · 2014 to 2018
$1.6M
Targeting cortical microglia to treat neuropathic painR21NS106469 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI YANG, GUANG · 2018 to 2019
$446k
NIGMS NIH HHS R01 GM107469NINDS NIH HHS R01 NS047325NINDS NIH HHS R21 NS106469
6 · The paper itself

Abstract

The anterior cingulate cortex (ACC) is thought to be important for acute pain perception as well as the development of chronic pain after peripheral nerve injury. Nevertheless, how ACC neurons respond to sensory stimulation under chronic pain states is not well understood. Here, we used an

Indexed as

acute painanterior cingulate cortex (ACC)neuropathic painpyramidal neuronstwo-photon imaging

Identifiers

PMID29731710
PMCPMC5919951
OpenAlexW2802693954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.