Evidence map›Paper›PMID 29731661›Full record

ArticleJournal of pain research2018

Electrophysiologic alterations in the excitability of the sciatic and vagus nerves during early stages of sepsis.

Lúcio Ricardo Leite Diniz, Viviane Gomes Portella, Kerly Shamira da Silva Alves, Pâmella Cristina da Costa Araújo, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Aline Alice Cavalcante de Albuquerque, Andrelina Noronha Coelho-de-Souza, José Henrique Leal-Cardoso

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In one paragraph

Article in Journal of pain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lúcio Ricardo Leite DinizDepartment of Physiology, Federal University of Sergipe, São Cristóvão, Brazil.
Viviane Gomes PortellaDepartment of Physiology, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
Kerly Shamira da Silva AlvesDepartment of Physiology, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
Pâmella Cristina da Costa AraújoDepartment of Physiology, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
Ricardo Luiz Cavalcanti de Albuquerque JúniorLaboratory of Morphology and Structural Biology, Science and Technology Institute - ITP, Aracaju, Brazil.
Aline Alice Cavalcante de AlbuquerqueDepartment of Physiology, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
Andrelina Noronha Coelho-de-SouzaDepartment of Physiology, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
José Henrique Leal-CardosoDepartment of Physiology, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, Brazil.
Universidade Estadual do Ceará · BRInstituto de Tecnologia e Pesquisa · BRUniversidade Federal de Sergipe · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonspecific and delayed diagnosis of neurologic damage contributes to the development of neuropathies in patients with severe sepsis. The present study assessed the electrophysiologic parameters related to the excitability and conductibility of sciatic and vagus nerves during early stages of sepsis. MATERIALS AND

methodsTwenty-four hours after sepsis induced by cecal ligation and puncture (CLP) model, sciatic and vagus nerves of septic (CLP group) and control (sham group) rats were removed, and selected electric stimulations were applied to measure the parameters of the first and second components of the compound action potential. The first component originated from fibers with motor and sensory functions (Types A

resultsWe observed an increase of rheobase followed by a decrease in the first component amplitude and a higher paw withdrawal threshold in response to the application of von Frey filaments in sciatic nerves from the CLP group compared to the sham group. Differently, a decrease in rheobase and an increase in the first component amplitude of vagal C fibers from CLP group were registered. No significant morphologic alteration was observed.

conclusionOur data showed that the electrophysiologic alterations in peripheral nerves vary with the fiber type and might be identified in the first 24 h of sepsis, before clinical signs of neuromuscular disorders.

Indexed as

neuronal excitabilityneuropathyperipheral nervessciatic nervesepsisvagus nerve

Identifiers

PMID29731661
PMCPMC5927063
OpenAlexW2802784791

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.