ArticleMolecular psychiatry2018
A genome-wide association study for extremely high intelligence.
Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Biological annotation of genetic loci associated with intelligence in a meta-analysis of 87,740 individuals.Molecular psychiatry · 2019Pooled it
- Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.Nature genetics · 2018Pooled it
- Overlap between genetic variants associated with schizophrenia spectrum disorders and intelligence quotient: a systematic review.Journal of psychiatry & neuroscience : JPNPooled it
- Diverse and location-specific roles of PlexinA2, PlexinA4, and NCAM in developing hippocampal mossy fibers.Translational psychiatry · 2026Article
- Familiality of the Intelligence Quotient in First Episode Psychosis: Is the Degree of Family Resemblance Associated With Different Profiles?Schizophrenia bulletin · 2024Article
- Article
- Polygenic risk scores of lithium response and treatment resistance in major depressive disorder.Translational psychiatry · 2023Article
- Investigating genetic overlap between antidepressant and lithium response and treatment resistance in major depressive disorder.Research square · 2023Article
- Neurodegenerative Diseases: From Dysproteostasis, Altered Calcium Signalosome to Selective Neuronal Vulnerability to AAV-Mediated Gene Therapy.International journal of molecular sciences · 2022Review
- Inferring intelligence of ancient people based on modern genomic studies.Journal of human genetics · 2022Article
- Review
- Neuroanatomical differences in the memory systems of intellectual giftedness and typical development.Brain and behavior · 2021Article
- Children's Greenness Exposure and IQ-Associated DNA Methylation: A Prospective Cohort Study.International journal of environmental research and public health · 2021Article
- Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia.Molecular psychiatry · 2021Article
- Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy.Molecular psychiatry · 2021Article
- A maximum flow-based network approach for identification of stable noncoding biomarkers associated with the multigenic neurological condition, autism.BioData mining · 2021Article
- Intellectual disability: dendritic anomalies and emerging genetic perspectives.Acta neuropathologica · 2021Review
- Identification of novel loci associated with infant cognitive ability.Molecular psychiatry · 2020Article
- The Mitochondrial Theory ofJournal of Intelligence · 2020Article
- Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference Panel.Frontiers in cell and developmental biology · 2020Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
We used a case-control genome-wide association (GWA) design with cases consisting of 1238 individuals from the top 0.0003 (~170 mean IQ) of the population distribution of intelligence and 8172 unselected population-based controls. The single-nucleotide polymorphism heritability for the extreme IQ trait was 0.33 (0.02), which is the highest so far for a cognitive phenotype, and significant genome-wide genetic correlations of 0.78 were observed with educational attainment and 0.86 with population IQ. Three variants in locus ADAM12 achieved genome-wide significance, although they did not replicate with published GWA analyses of normal-range IQ or educational attainment. A genome-wide polygenic score constructed from the GWA results accounted for 1.6% of the variance of intelligence in the normal range in an unselected sample of 3414 individuals, which is comparable to the variance explained by GWA studies of intelligence with substantially larger sample sizes. The gene family plexins, members of which are mutated in several monogenic neurodevelopmental disorders, was significantly enriched for associations with high IQ. This study shows the utility of extreme trait selection for genetic study of intelligence and suggests that extremely high intelligence is continuous genetically with normal-range intelligence in the population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.