ArticleNeuron2018
A Brain-wide Circuit Model of Heat-Evoked Swimming Behavior in Larval Zebrafish.
Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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Who cites it
52 citing papers in PubMed, 109 citations in OpenAlex.
- Article
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
- Modulation of habenula axon terminals supports action-outcome associations in larval zebrafish.Nature communications · 2026Article
- Experience-dependent modulation of collective behavior in larval zebrafish.Nature communications · 2026Article
- PGE2 modulation of stimulus valence directs zebrafish behavioral fever.bioRxiv : the preprint server for biology · 2026Article
- Neural temporal scaling accounts for robust hunting behavior across temperatures.Nature communications · 2026Article
- Behavioral, physiological, encephalopathological alterations and endoplasmic reticulum stress/apoptotic-related gene transcription in reaction to heat stress in Oreochromis niloticus fish: impact of dietary supplements with Spirulina-Coenzyme Q10 nanoemulsion.Veterinary research communications · 2026Article
- Linking brain and behavior states in Zebrafish Larvae locomotion using hidden Markov models.PLoS computational biology · 2026Article
- Behavioral and circuit principles of temperature gradient navigation.Current biology : CB · 2025Article
- Integrative functional optical imaging approaches: Optics, microfluidics, and machine learning for neuroscience in organoids and small-animal models.Biophysical journal · 2025Review
- Temperature and photoperiod stress in zebrafish larvae: impacts on development, gene regulation and PGC migration.Fish physiology and biochemistry · 2025Article
- Sensorimotor integration enhances temperature stimulus processing.PLoS computational biology · 2025Article
- Heat Acclimation Enhances Brain Resilience to Acute Thermal Stress inAnimals : an open access journal from MDPI · 2025Article
- BIFROST: A method for registering diverse imaging datasets of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Molecular underpinnings underlying behaviors changes in the brain of juvenile common carp (Cyrinus carpio) in response to warming.Journal of advanced research · 2024Article
- Vertebrate behavioral thermoregulation: knowledge and future directions.Neurophotonics · 2024Review
- Network Statistics of the Whole-Brain Connectome ofbioRxiv : the preprint server for biology · 2024Article
- The preoptic area and dorsal habenula jointly support homeostatic navigation in larval zebrafish.Current biology : CB · 2024Article
- Transcriptome Analysis Revealed the Early Heat Stress Response in the Brain of Chinese Tongue Sole (Animals : an open access journal from MDPI · 2023Article
- Functional and pharmacological analyses of visual habituation learning in larval zebrafish.eLife · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Thermosensation provides crucial information, but how temperature representation is transformed from sensation to behavior is poorly understood. Here, we report a preparation that allows control of heat delivery to zebrafish larvae while monitoring motor output and imaging whole-brain calcium signals, thereby uncovering algorithmic and computational rules that couple dynamics of heat modulation, neural activity and swimming behavior. This approach identifies a critical step in the transformation of temperature representation between the sensory trigeminal ganglia and the hindbrain: A simple sustained trigeminal stimulus representation is transformed into a representation of absolute temperature as well as temperature changes in the hindbrain that explains the observed motor output. An activity constrained dynamic circuit model captures the most prominent aspects of these sensori-motor transformations and predicts both behavior and neural activity in response to novel heat stimuli. These findings provide the first algorithmic description of heat processing from sensory input to behavioral output.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.