ArticleNeuron2018
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families.
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Article in Neuron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers, 4 of them syntheses that pooled it.
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40citing papers in PubMed, 4 pooled it
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Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- What does a migraine aura look like?-A systematic review.The journal of headache and pain · 2025Pooled it
- Genome-wide association meta-analyses of drug-resistant epilepsy.EBioMedicine · 2025Pooled it
- Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.Nature genetics · 2022Pooled it
- An underrepresented majority: A systematic review utilizing allodynic criteria to examine the present scarcity of discrete animal models for episodic migraine.Cephalalgia : an international journal of headache · 2021Pooled it
- Hemiplegic migraine: genetics and pathophysiology.The Journal of clinical investigation · 2026Review
- Preimplantation genetic testing for polygenic diseases: A novel paradigm in embryo selection.Biochemistry and biophysics reports · 2026Review
- Post-Traumatic Headache in Children and Genetic Risk of Migraine: An Observational Cohort Study.Neurology. Genetics · 2026Article
- Integrative Migraine Therapy: From Current Concepts to Future Directions-A Plastic Surgeon's Perspective.Medicina (Kaunas, Lithuania) · 2025Review
- Article
- Prediction of new-onset migraine using clinical-genotypic data from the HUNT Study: a machine learning analysis.The journal of headache and pain · 2025Article
- Mechanisms underlying CSD initiation implicated by genetic mouse models of migraine.The journal of headache and pain · 2025Review
- Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024Review
- An Integrative Migraine Polygenic Risk Score Is Associated with Age at Onset But Not Chronification.Journal of clinical medicine · 2024Article
- Review
- Clinical characteristics of headaches in an urban Mennonite group in South Brazil.Arquivos de neuro-psiquiatria · 2023Article
- Whole Exome Sequencing of Hemiplegic Migraine Patients Shows an Increased Burden of Missense Variants in CACNA1H and CACNA1I Genes.Molecular neurobiology · 2023Article
- Genetics of migraine: where are we now?The journal of headache and pain · 2023Review
- Cluster and network analysis of non-headache symptoms in migraine patients reveals distinct subgroups based on onset age and vestibular-cochlear symptom interconnection.Frontiers in neurology · 2023Article
- Genome-phenome wide association study of broadly defined headache.Brain communications · 2023Article
- Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families.Cephalalgia : an international journal of headache · 2022Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
41 authors.
Padhraig GormleyMassachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Mitja I KurkiMassachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Marjo Eveliina HiekkalaInstitute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Kumar VeerapenMassachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Paavo HäppöläInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Adele A MitchellMerck Research Laboratories, Merck and Co., Kenilworth, NJ, USA.
Dennis LalMassachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Cologne Center for Genomics, University of Cologne, Cologne, Germany.
Priit PaltaInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Ida SurakkaInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Mari Anneli KaunistoInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Eija HämäläinenInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Salli VepsäläinenDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Hannele HavankaRegional State Administrative Agency for Northern Finland, Oulu, Finland.
Hanna HarnoDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland; Division of Pain Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Finland.
Matti IlmavirtaDepartment of Neurology, Central Hospital Central Finland, Jyväskylä.
Markku NissiläTerveystalo Clinical Research, Turku, Finland.
Erkki SäköTurku Headache Center, Turku, Finland.
Marja-Liisa SumelahtiTerveystalo, Tampere, Finland.
Jarmo LiukkonenLääkärikeskus Ikioma, Mikkeli, Finland.
Matti SillanpääDepartments of Child Neurology and General Practice, University of Turku, and Turku University Hospital, Turku, Finland.
Liisa MetsähonkalaEpilepsy Unit for Children and Adolescents, Helsinki University Hospital, Helsinki, Finland.
Seppo KoskinenNational Institute for Health and Welfare, Helsinki, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Faculty of Medicine and Life Sciences, University of Tampere, Finland.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Minna MännikköNorthern Finland Birth Cohorts, Faculty of Medicine, University of Oulu, Oulu, Finland.
Caroline RanDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Andrea Carmine BelinDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Pekka JousilahtiNational Institute for Health and Welfare, Helsinki, Finland.
Verneri AnttilaMassachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland.
Ville ArttoDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Markus FärkkiläDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
23andMe Research Team23andMe, Inc., Mountain View, CA, USA.
International Headache Genetics Consortium (IHGC)
Heiko RunzMerck Research Laboratories, Merck and Co., Kenilworth, NJ, USA.
Mark J DalyMassachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Benjamin M NealeMassachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Samuli RipattiInstitute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Public Health, Faculty of Medicine, University of Helsinki, Finland.
Mikko KallelaDepartment of Neurology, Helsinki University Central Hospital, Helsinki, Finland.
Maija WessmanInstitute of Genetics, Folkhälsan Research Center, Helsinki, Finland; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
Aarno PalotieMassachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland. Electronic address: aarno.palotie@helsinki.fi.
Funding
2/2 Genomic strategies to identify high-impact psychiatric risk variantsU01MH105666 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI PALOTIE, AARNO · 2014 to 2018
$1.0MNIMH NIH HHS U01 MH105666Wellcome Trust 098051
Abstract
Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses. In 8,319 individuals across 1,589 migraine families, we calculated migraine polygenic risk scores (PRS) and found a significantly higher common variant burden in familial cases (n = 5,317, OR = 1.76, 95% CI = 1.71-1.81, p = 1.7 × 10
Indexed as
Genetic Predisposition to DiseaseGenetic VariationAdultFemaleGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedMigraine DisordersMigraine with AuraMigraine without AuraMultifactorial InheritancePhenotypedisease aggregationfamilial aggregationfamiliesgenome-wide association studyGWAShemiplegic migrainemigrainemigraine with aurapolygenic risk scorePRS
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