Evidence map›Paper›PMID 29730892›Full record

ArticleStem cells translational medicine2018

Activation of p70S6 Kinase-1 in Mesenchymal Stem Cells Is Essential to Lung Tissue Repair.

Katsuyuki Takeda, Fangkun Ning, Joanne Domenico, Masakazu Okamoto, Shigeru Ashino, Sang-Ha Kim, Yi Yeong Jeong, Yoshiki Shiraishi, Naohiro Terada, Everett Rand Sutherland and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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  12. Regeneration and repair in the healing lung.Clinical & translational immunology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Katsuyuki TakedaDivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.ORCID 0000-0003-1623-3573
Fangkun NingDivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
Joanne DomenicoDivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
Masakazu OkamotoDivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
Shigeru AshinoDivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
Sang-Ha KimDivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
Yi Yeong JeongDivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
Yoshiki ShiraishiDivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
Naohiro TeradaDepartment of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.
Everett Rand SutherlandImmunology & Inflammation Development Franchise, Sanofi Genzyme, Cambridge, Massachusetts, USA.
Erwin W GelfandDivision of Cell Biology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA.
National Jewish Health · USUniversity of Colorado Denver · USFlorida College · USSanofi (France) · FR

Funding

PREPARATION AND DISTRUBUTION OF ADULT STEM CELLS: HUMAN &RODENTP40RR017447 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI PROCKOP, DARWIN JOHNSON · 2003 to 2011
$8.9M
NCRR NIH HHS P40 RR017447
6 · The paper itself

Abstract

All-trans retinoic acid (ATRA) or mesenchymal stem cells (MSCs) have been shown to promote lung tissue regeneration in animal models of emphysema. However, the reparative effects of the combination of the two and the role of p70S6 kinase-1 (p70S6k1) activation in the repair process have not been defined. Twenty-one days after intratracheal instillation of porcine pancreatic elastase (PPE), MSC and/or 10 days of ATRA treatment was initiated. Thirty-two days later, static lung compliance (Cst), mean linear intercepts (MLIs), and alveolar surface area (S) were measured. After PPE, mice demonstrated increased values of Cst and MLI, and decreased S values. Both ATRA and MSC transfer were individually effective in improving these outcomes while the combination of ATRA and MSCs was even more effective. The combination of p70S6k1

Indexed as

Mesenchymal Stem Cell TransplantationAnimalsBone Marrow CellsDisease Models, AnimalFemaleLungMesenchymal Stem CellsMiceMice, Inbred C57BLPancreatic ElastasePhosphorylationPulmonary EmphysemaRegenerationRibosomal Protein S6 Kinases, 70-kDaTissue EngineeringTretinoinPancreatic Elastaseribosomal protein S6 kinase, 70kD, polypeptide 2Ribosomal Protein S6 Kinases, 70-kDaTretinoinAnimal modelsCell signalingCellular therapyMesenchymal stem cellsTissue regeneration

Identifiers

PMID29730892
PMCPMC6052610
OpenAlexW2799996925

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.