ArticleJournal of materials science. Materials in medicine2018
Chitosan/gelatin scaffolds support bone regeneration.
Article in Journal of materials science. Materials in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 93 citations in OpenAlex.
- Effect of Sulfated Polysaccharides and Laponite in Composite Porous Scaffolds on Osteogenesis.Biomolecules · 2026Article
- Starch-Gelatin-Based Scaffolds for Cartilage Defect Repair: An in vitro Study Supporting Its Potential Clinical Use.Cartilage · 2025Article
- Fabrication and evaluation of a host-guest polylactic acid/gelatin-hydroxyapatite-blueberry scaffold for bone regeneration.Journal of orthopaedic surgery and research · 2025Article
- Purified bone xenografts: A novel and efficient animal bone substitute derived from an optimized supercritical COMaterials today. Bio · 2025Article
- Review
- Categories, applications, and potential of stem cells in bone regeneration: an overview.Frontiers in medicine · 2025Review
- Chitosan-based Nano/Biomaterials in Bone Tissue Engineering and Regenerative Medicine: Recent Progress and Advances.Current organic synthesis · 2025Review
- Innovative modification strategies and emerging applications of natural hydrogel scaffolds for osteoporotic bone defect regeneration.Frontiers in bioengineering and biotechnology · 2025Review
- Physically Crosslinked Poly(methacrylic acid)/Gelatin Hydrogels with Excellent Fatigue Resistance and Shape Memory Properties.Gels (Basel, Switzerland) · 2024Article
- A 3D-Printed Scaffold for Repairing Bone Defects.Polymers · 2024Review
- Article
- Effectiveness of Bilayer Scaffold Containing Chitosan/Gelatin/Diclofenac and Bovine Hydroxyapatite on Cartilage/Subchondral Regeneration in Rabbit Joint Defect Models.Advances in pharmacological and pharmaceutical sciences · 2024Article
- Synthetic Calcium-Phosphate Materials for Bone Grafting.Polymers · 2023Review
- The Diamond Concept Enigma: Recent Trends of Its Implementation in Cross-linked Chitosan-Based Scaffolds for Bone Tissue Engineering.ACS applied bio materials · 2023Review
- Review
- Effect of Uniaxial Compression Frequency on Osteogenic Cell Responses in Dynamic 3D Cultures.Bioengineering (Basel, Switzerland) · 2023Article
- Kappa-Carrageenan/Chitosan/Gelatin Scaffolds Provide a Biomimetic Microenvironment for Dentin-Pulp Regeneration.International journal of molecular sciences · 2023Article
- Chitosan-Based Biomaterials for Tissue Regeneration.Pharmaceutics · 2023Review
- Chitosan/Gelatin Scaffolds Loaded withPolymers · 2023Article
- An Investigation of the Sol-Gel Transition of Chitosan Lactate and Chitosan Chloride Solutions via Rheological and NMR Studies.Gels (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Chitosan/Gelatin (CS:Gel) scaffolds were fabricated by chemical crosslinking with glutaraldehyde or genipin by freeze drying. Both crosslinked CS:Gel scaffold types with a mass ratio of 40:60% form a gel-like structure with interconnected pores. Dynamic rheological measurements provided similar values for the storage modulus and the loss modulus of the CS:Gel scaffolds when crosslinked with the same concentration of glutaraldehyde vs. genipin. Compared to genipin, the glutaraldehyde-crosslinked scaffolds supported strong adhesion and infiltration of pre-osteoblasts within the pores as well as survival and proliferation of both MC3T3-E1 pre-osteoblastic cells after 7 days in culture, and human bone marrow mesenchymal stem cells (BM-MSCs) after 14 days in culture. The levels of collagen secreted into the extracellular matrix by the pre-osteoblasts cultured for 4 and 7 days on the CS:Gel scaffolds, significantly increased when compared to the tissue culture polystyrene (TCPS) control surface. Human BM-MSCs attached and infiltrated within the pores of the CS:Gel scaffolds allowing for a significant increase of the osteogenic gene expression of RUNX2, ALP, and OSC. Histological data following implantation of a CS:Gel scaffold into a mouse femur demonstrated that the scaffolds support the formation of extracellular matrix, while fibroblasts surrounding the porous scaffold produce collagen with minimal inflammatory reaction. These results show the potential of CS:Gel scaffolds to support new tissue formation and thus provide a promising strategy for bone tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.