Evidence map›Paper›PMID 29730840›Full record

ArticleLa Radiologia medica2018

Technical and clinical feasibility of contrast-enhanced ultrasound evaluation of long bone non-infected nonunion healing.

Simona Pozza, Armanda De Marchi, Chiara Albertin, Domenico Albano, Ginevra Biino, Domenico Aloj, Luca Maria Sconfienza

Abstract read
PubMed Publisher
In one paragraph

Article in La Radiologia medica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Ultrasound of iliotibial band syndrome.Journal of ultrasound · 2020
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simona PozzaDepartment of Imaging, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126, Turin, Italy.
Armanda De MarchiDepartment of Imaging, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, CTO Hospital, Via Zuretti 29, 10126, Turin, Italy.
Chiara AlbertinDepartment of Imaging, Ospedale Humanitas Gradenigo, C.so Regina Margherita 8, 10153, Turin, Italy.
Domenico AlbanoDepartment of Radiology, Di.Bi.Med., University of Palermo, Via del Vespro 127, 90127, Palermo, Italy. albanodomenico@me.com.ORCID http://orcid.org/0000-0001-7989-9861
Ginevra BiinoInstitute of Molecular Genetics, National Research Council of Italy, Via Ferrata, 27100, Pavia, Italy.
Domenico AlojDepartment of Orthopedics and Traumatology, Sant'Andrea Hospital, C.so Abbiate 21, 13100, Vercelli, Italy.
Luca Maria SconfienzaUnit of Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi 4, 20166, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the technical feasibility of contrast-enhanced ultrasound (CEUS) in the monitoring of non-infected long bone nonunion healing.

methodsTwenty-five patients (16 males; mean age: 40.4 ± 11.7) with long bone nonunion were treated using surgery and mesenchymal stem cells and platelet-rich plasma. They performed CEUS up to 15 days before, 7 days, 4 and 8 weeks after treatment. To categorize the angiogenesis around the fracture site, the microvascular blood flow from CEUS was classified into four categories, depending on the portion of the investigated area that was involved in the neovascularization process: grade 0 = 0%; grade 1 = 0-30%; grade 2 = 30-70%; grade 3 = 70-100%. Nonparametric Friedman and Wilcoxon statistics were used.

resultsBefore treatment, neovascularization was graded as 0 in 15/25 patients, as 1 in 10/25. Vascularity significantly increased over time (P < 0.001), namely: 1 (25th-75th percentile = 1-2) at 7 days; 2 (1-2) at 4 weeks; 3 (0-2) at 8 weeks. All patients but one showed early progressive increase in neovascularization well identified with CEUS at the fracture site.

conclusionCEUS is a feasible method to monitor healing in patients with long bone nonunion.

Indexed as

AdultContrast MediaDebridementFeasibility StudiesFemaleFracture FixationFractures, BoneFractures, UnunitedHumansMaleMesenchymal Stem Cell TransplantationMiddle AgedNeovascularization, PhysiologicPlatelet-Rich PlasmaRetrospective StudiesRisk FactorsContrast MediaContrast-enhanced ultrasoundLong bone nonunionMesenchymal stem cellsPlatelet-rich plasmaUltrasound

Identifiers

PMID29730840

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.