Evidence map›Paper›PMID 29730819›Full record

ArticleInflammation2018

Artesunate Inhibits Renal Ischemia-Reperfusion-Mediated Remote Lung Inflammation Through Attenuating ROS-Induced Activation of NLRP3 Inflammasome.

Zhaohui Liu, Min Qu, Lili Yu, Panpan Song, Yulin Chang

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
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  6. Article
  7. Article
  8. Role of mitochondrial stress and the NLRP3 inflammasome in lung diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Paraquat Induces Lung InjuryFrontiers in pharmacology · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhaohui LiuDepartment of Anesthesiology, Cangzhou Central Hospital, Hebei Medical University, No.16 Xinhua West Road, Yunhe District, Cangzhou, Hebei, China. zhaohuiliu666@hotmail.com.ORCID http://orcid.org/0000-0002-7467-9795
Min QuDepartment of Anesthesiology, Cangzhou Central Hospital, Hebei Medical University, No.16 Xinhua West Road, Yunhe District, Cangzhou, Hebei, China.
Lili YuDepartment of Anesthesiology, Cangzhou Central Hospital, Hebei Medical University, No.16 Xinhua West Road, Yunhe District, Cangzhou, Hebei, China.
Panpan SongDepartment of Anesthesiology, Cangzhou Central Hospital, Hebei Medical University, No.16 Xinhua West Road, Yunhe District, Cangzhou, Hebei, China.
Yulin ChangDepartment of Anesthesiology, Cangzhou Central Hospital, Hebei Medical University, No.16 Xinhua West Road, Yunhe District, Cangzhou, Hebei, China.
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular mechanisms of acute lung injury (ALI) are closely associated with nucleotide-binding domains and leucine-rich repeat (NLR) pyrin domains containing 3 (NLRP3) inflammasome, in which alveolar macrophages (AMs) exert an essential function. Our study has been proved that artesunate (AS) inhibits ALI. Nevertheless, the inhibition actions of AS on activation of NLRP3 in renal ischemia-reperfusion (RIR)-mediated ALI remain to be further discussed. Male Sprague-Dawley rats were randomly assigned into four groups: sham + NS, sham + AS, RIR + NS, and RIR + AS. RIR-mediated ALI was performed through bilateral renal pedicle occlusion for 60 min followed by reperfusion for 24 h. AS (15 mg/kg) or NS was injected intraperitoneal to rat 1 h before RIR treatment. AMs were rendered hypoxic (0.5%) for 2 h and reoxygenated for 24 h. Lung injury index and histology, and inflammatory cells and cytokine release in the BALF and AMs were examined. The protein and mRNA levels of NLRP3, ASC, and caspase-1 in the lung and AMs were evaluated via Western blot and real-time RCR. In this research, we indicated that AS preconditioning inhibited RIR-mediated lung damage, vascular permeability, and edema in rats. AS reduced RIR-mediated ALI, as characterized by abatement in the count of inflammatory cells, and the production of inflammatory cytokines in the BALF. AS administration inhibited the number of F4/80-positive cells, the activity of myeloperoxidase, and the fiery cytokines mRNA expression in lung samples of RIR-stimulated rats. Furthermore, AS alleviated the activity of caspase-1 and activation of NLRP3 through depending on reactive oxygen species (ROS). An in vitro finding that AS mitigated hypoxia/reoxygenation-mediated activation of AMs partially supported in vivo study. In a word, these findings demonstrate that AS pretreatment attenuated RIR-mediated ALI potentially through reducing ROS-induced activation of the NLRP3 inflammasome.

Indexed as

Acute Lung InjuryAmebicidesAnimalsArtemisininsArtesunateInflammasomesKidneyMaleNLR Family, Pyrin Domain-Containing 3 ProteinPneumoniaRatsRats, Sprague-DawleyReactive Oxygen SpeciesReperfusion InjuryAmebicidesArtemisininsArtesunateInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen Speciesacute lung injuryartesunatenucleotide-binding domain and leucine-rich repeat pyrin domain containing 3reactive oxygen speciesrenal ischemia-reperfusion injury

Identifiers

PMID29730819
OpenAlexW2802303010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.