Evidence map›Paper›PMID 29730752›Full record

ArticleExperimental brain research2018

Unilateral wrist extension training after stroke improves strength and neural plasticity in both arms.

Yao Sun, Noah M H Ledwell, Lara A Boyd, E Paul Zehr

Abstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  13. Botulinum Toxin and Dynamic Splint Restore Grasping Function after Stroke: A Case Report.International journal of environmental research and public health · 2023
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  19. How does cross-education affects muscles of paretic upper extremity in subacute stroke survivors?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yao SunRehabilitation Neuroscience Laboratory, University of Victoria, Victoria, BC, V8P5C2, Canada.ORCID http://orcid.org/0000-0002-0178-3612
Noah M H LedwellBrain Behaviour Laboratory, University of British Columbia, Vancouver, BC, V6T1Z3, Canada.
Lara A BoydBrain Behaviour Laboratory, University of British Columbia, Vancouver, BC, V6T1Z3, Canada.
E Paul ZehrRehabilitation Neuroscience Laboratory, University of Victoria, Victoria, BC, V8P5C2, Canada. pzehr@uvic.ca.
University of British Columbia · CAUniversity of Victoria · CA

Funding

Canadian Institutes of Health Research MOP-106651
6 · The paper itself

Abstract

Stroke induces bilateral neurological impairment and muscle weakness yielding neurologically more (MA; paretic) and less affected (LA; non-paretic) sides. "Cross-education" refers to training one side of the body to increase strength in the same muscles on the untrained side. Past work showed dorsiflexion training of the LA side produced bilateral strength increases after stroke. The current study explored the presence and extent of cross-education after arm strength training in chronic stroke. Twenty-four chronic stroke participants completed 5 weeks of maximal wrist extension training using their LA arm. Maximal voluntary contraction force, arm motor impairment and functional performance were measured before and after training. Both spinal cord plasticity (n = 12: reciprocal inhibition and cutaneous reflexes, University of Victoria) and cortical plasticity (n = 12: cortical silent period, short-interval intracortical inhibition, intracortical facilitation and transcallosal inhibition, University of British Columbia) were assessed. Five weeks after training, 20 participants completed a follow-up maximal wrist extension retention test. LA wrist extension force increased 42% and MA by 35%. Strength gains were maintained in the follow-up test. Clinically meaningful increases in Fugl-Meyer scores were noted in four participants. Muscle activation was correlated with cutaneous reflex amplitudes after training in the MA arm. LA cortical silent period and transcallosal inhibition from both hemispheres significantly decreased after training. This study shows that high-intensity training with the neurologically less affected "non-paretic" arm can improve strength bilaterally and alter both spinal and cortical plasticity. The extent to which this plasticity can be enhanced or functionally exploited remains to be examined.

Indexed as

Stroke RehabilitationAdultAnalysis of VarianceCortical Spreading DepressionFemaleFollow-Up StudiesHumansIsometric ContractionMaleMuscle StrengthNeural InhibitionNeuronal PlasticityPsychomotor PerformanceResistance TrainingSeverity of Illness IndexStrokeCross-educationNeuroplasticityRehabilitationStrength trainingStroke

Identifiers

PMID29730752
OpenAlexW2800087554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.