ArticlePsychopharmacology2018
Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Genetics of Risk Aversion: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Arbitration between model-free and model-based control is not affected by transient changes in tonic serotonin levels.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Acute tryptophan loading decreases functional connectivity between the default mode network and emotion-related brain regions.Human brain mapping · 2019Trial
- Differential susceptibility effects of theFrontiers in psychiatry · 2025Article
- Connection Failure: Differences in White Matter Microstructure Are Associated withInternational journal of molecular sciences · 2024Article
- Constitutive depletion of brain serotonin differentially affects rats' social and cognitive abilities.iScience · 2023Article
- The Effects of Citalopram and Thalamic Dopamine DPsychiatry journal · 2022Article
- The Role of Tryptophan and Tyrosine in Executive Function and Reward Processing.International journal of tryptophan research : IJTR · 2020Review
- Baseline impulsivity may moderate L-DOPA effects on value-based decision-making.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
rationaleSerotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making.
objectivesTo test whether high 5-HT levels decrease loss aversion, risk-seeking for gains, and risk-seeking for losses.
methodsIn a first session, 611 participants were genotyped for 5-HTTLPR and performed a mixed gambles (MGA) task and two probability discounting tasks for gains and losses, respectively (PDG/PDL). Afterwards, a subsample of 105 participants (44 with S/S, 6 with S/L, 55 with L/L genotype) completed the pharmacological study using a crossover design with tryptophan depletion (ATD), loading (ATL), and balanced (BAL) conditions. The same decision constructs were assessed.
resultsWe found increased risk-seeking for losses in S/S compared to L/L individuals at the first visit (p = 0.002). Neither tryptophan depletion nor loading affected decision-making, nor did we observe an interaction between intervention and 5-HTTLPR genotype.
conclusionOur data do not support the idea that transient changes of tonic 5-HT affect value-based decision-making. We provide evidence for an association of 5-HTTLPR with risk-seeking for losses, independent of acute 5-HT levels. This indicates that the association of 5-HTTLPR and risk-seeking for losses is mediated via other mechanisms, possibly by differences in the structural development of neural circuits of the 5-HT system during early life phases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.