ArticleFetal diagnosis and therapy2019
Perinatal Outcome and Long-Term Neurodevelopment after Intracranial Haemorrhage due to Fetal and Neonatal Alloimmune Thrombocytopenia.
Article in Fetal diagnosis and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04529382 (Neurodevelopmental Outcome After Fetal Neonatal AlloImmune Thrombocytopenia), which is not on this map. Cited by 13 papers.
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Neurodevelopmental Outcome After Fetal Neonatal AlloImmune Thrombocytopenia
Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Maternal-fetal platelet alloimmunization: Identification of risk factors for severe neonatal thrombocytopenia.Transfusion · 2026Article
- New perspectives on fetal and neonatal alloimmune thrombocytopenia for obstetricians.Frontiers in immunology · 2026Review
- Improving prediction of fetal/neonatal intracranial hemorrhage in HPA-1a alloimmunized pregnancies to guide antenatal management: An observational cohort study.Acta obstetricia et gynecologica Scandinavica · 2025Observational
- Diagnosis and Management of Fetal and Neonatal Alloimmune Thrombocytopenia: An Update 2025.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025Review
- Screening of pregnant women for foetal neonatal alloimmune thrombocytopenia: A cost-utility analysis.Vox sanguinis · 2025Article
- Prenatal diagnosis and postnatal outcome of fetal intracranial hemorrhage: a single-center experience.Obstetrics & gynecology science · 2024Article
- Short-Term and Long-Term Outcomes of Fetal Ventriculomegaly beyond Gestational 37 Weeks: A Retrospective Cohort Study.Journal of clinical medicine · 2023Article
- Fetal intracranial hemorrhage: prenatal sonographic diagnosis criteria and postnatal outcomesJournal of the Turkish German Gynecological Association · 2022Article
- Clinical characteristics of human platelet antigen (HPA)-1a and HPA-5b alloimmunised pregnancies and the association between platelet HPA-5b antibodies and symptomatic fetal neonatal alloimmune thrombocytopenia.British journal of haematology · 2021Article
- Placental Complement Activation in Fetal and Neonatal Alloimmune Thrombocytopenia: An Observational Study.International journal of molecular sciences · 2021Observational
- Characterization of glycoprotein IIb/IIIa-specific alloantibodies induced by cross-strain platelet immunization in mice.Transfusion · 2021Article
- Article
- Outcome Trajectories after Primary Perinatal Hemorrhagic Stroke.Pediatric neurology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the perinatal and long-term neurodevelopmental outcome in a cohort of children with intracranial haemorrhage (ICH) due to fetal and neonatal alloimmune thrombocytopenia (FNAIT) and to clearly outline the burden of this disease. SUBJECTS AND
methodsWe performed an observational cohort study and included all consecutive cases of ICH caused by FNAIT from 1993 to 2015 at Leiden University Medical Centre. Neurological, motor, and cognitive development were assessed at a minimum age of 1 year. The primary outcome was adverse outcome, defined as perinatal death or severe neurodevelopmental impairment (NDI). Severe NDI was defined as any of the following: cerebral palsy (Gross Motor Function Classification System [GMFCS] level ≥II), bilateral deafness, blindness, or severe motor and/or cognitive developmental delay (<-2 SD).
resultsIn total, 21 cases of ICH due to FNAIT were included in the study. The perinatal mortality rate was 10/21 (48%). Long-term outcome was assessed in 10 children (n = 1 lost to follow-up). Severe and moderate NDI were diagnosed in 6/10 (60%) and 1/10 (10%) of the surviving children. The overall adverse outcome, including perinatal mortality or severe NDI, was 16/20 (80%).
conclusionsThe risk of perinatal death or severe NDI in children with ICH due to FNAIT is high. Only screening and effective preventive treatment can avoid this burden.
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