Evidence map›Paper›PMID 29730571›Full record

ReviewStem cell research2018

Spermatogonial stem cells and spermatogenesis in mice, monkeys and men.

Adetunji P Fayomi, Kyle E Orwig

Open access · goldAbstract readReview
In one paragraph

Review in Stem cell research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed
31.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 353 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Generation of Stra8-Cre/ERT2 Mouse Activator Strain for Inducible Cre-lox Recombination in Spermatocytes.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2026
    Article
  11. Exploration of Novel Markers in Tan Sheep Spermatogenesis.Animals : an open access journal from MDPI · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Adolescent exposure to Δ9-tetrahydrocannabinol impairs testicular function in young adult male mice.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  19. Review
  20. Review

140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Adetunji P FayomiMolecular Genetics and Developmental Biology Graduate Program, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States.
Kyle E OrwigMolecular Genetics and Developmental Biology Graduate Program, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States. Electronic address: orwigke@upmc.edu.
University of Pittsburgh · US

Funding

Transplant CoreP01HD075795 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ORWIG, KYLE EDWIN · 2014 to 2018
$7.0M
Characterization of male germline stem cells in a rhesus model of infertilityR01HD055475 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ORWIG, KYLE EDWIN · 2008 to 2012
$3.5M
Cellular Mechanisms of Chemotherapy-induced Male Infertility: Stem Cell or Niche?R01HD076412 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ORWIG, KYLE EDWIN · 2014 to 2018
$3.0M
Improving Fertility Preservation in Boys with CancerR01HD092084 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ORWIG, KYLE EDWIN · 2017 to 2019
$1.1M
New Fertility Preserving Option for Male Cancer SurvivorsR21HD061289 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ORWIG, KYLE EDWIN · 2010 to 2011
$425k
NICHD NIH HHS P01 HD075795NICHD NIH HHS R01 HD055475NICHD NIH HHS R01 HD076412NICHD NIH HHS R01 HD092084NICHD NIH HHS R21 HD061289
6 · The paper itself

Abstract

Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with differentiating divisions that sustain continuous sperm production. Rodent stem and progenitor spermatogonia are described by their clonal arrangement in the seminiferous epithelium (e.g., A

Indexed as

Adult Germline Stem CellsAnimalsCell DifferentiationCell LineageHaplorhiniHumansMaleMiceSpecies SpecificitySpermatogenesisA(dark)A(pale)Male fertilitySpermatogenic lineage developmentSpermatogonial stem cellsStem cellsTestis

Identifiers

PMID29730571
PMCPMC6010318
OpenAlexW2800761804

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.