Observational studyEpilepsy & behavior : E&B2018
Changes in antiepileptic drug-prescribing patterns in pregnant women with epilepsy.
Observational study in Epilepsy & behavior : E&B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 90 citations in OpenAlex.
- The Menopause Transition and Epilepsy: A Focus on Therapeutics.Neurology. Clinical practice · 2026Review
- Breastfeeding and Neurodevelopmental Outcomes in Children of Women Taking Antiseizure Medications.JAMA network open · 2026Observational
- Development of cerebral lateralization in children exposed to fetal antiseizure medications: A prospective cohort study at age 6 years.Epilepsia · 2026Article
- Age- and sex-associated variability in lamotrigine prescription patterns and clearance.Epilepsia · 2026Article
- New onset refractory status epilepticus diagnosed in the second trimester: A case report.Obstetric medicine · 2025Article
- Trends in Prenatal Exposure to Antiseizure Medications Over the Past Decade: A Nationwide Study.Neurology · 2025Article
- Characterization of lamotrigine disposition changes during and after pregnancy in women with epilepsy.Pharmacotherapy · 2025Observational
- Development and internal validation of a prognostic model for predicting tonic-clonic seizures during pregnancy in women with epilepsy.BMC pregnancy and childbirth · 2024Article
- Association of Prenatal Exposure to Antiseizure Medications With Creative and Executive Function at Age 4.5 Years.Neurology · 2024Observational
- Trends of antiseizure medication utilization among pregnant people in four Canadian provinces from 1998 to 2023; a study from the Canadian mother-child cohort active surveillance initiative (CAMCCO).Frontiers in pharmacology · 2024Article
- Issues of Women with Epilepsy and Suitable Antiseizure Drugs.Journal of epilepsy research · 2023Review
- Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy.Military medicine · 2023Article
- Utilization of Antiseizure Medications in Women of Childbearing Age With Epilepsy and Nonepilepsy Indications: A Retrospective Cohort Study.Neurology · 2023Article
- Healthcare professionals' information need related to antiseizure medication use in breastfeeding patients with epilepsy. Retrospective analysis of enquiries to Norwegian medicines information and pharmacovigilance centers.Epilepsy & behavior reports · 2023Article
- Women of childbearing age: What antiseizure medications are they taking?British journal of clinical pharmacology · 2023Article
- Management of Anti-Seizure Medications during Pregnancy: Advancements in The Past Decade.Pharmaceutics · 2022Review
- Patterns of antiseizure medication prescription in pregnancy and maternal complications in women with epilepsy: A retrospective study in Saudi Arabia.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Neurodevelopmental outcomes in children exposed prenatally to levetiracetam.Therapeutic advances in drug safety · 2022Review
- Structure-Activity Relationship (SAR) Model for Predicting Teratogenic Risk of Antiseizure Medications in Pregnancy by Using Support Vector Machine.Frontiers in pharmacology · 2022Article
- Neonatal Outcomes in the MONEAD Study of Pregnant Women with Epilepsy.The journal of pediatrics: X · 2021Article
Corrections and comments
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Authors and funding
15 authors at 12 institutions in 1 country.
Funding
Abstract
objectiveWe analyzed current prescribing patterns for antiepileptic drugs (AEDs) in pregnant women with epilepsy (PWWE) at 20 USA tertiary epilepsy centers.
methodsThe Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) study is an NIH-funded, prospective, observational, multicenter investigation of pregnancy outcomes for both mother and child, which enrolled women from December 2012 to January 2016. Inclusion criteria for PWWE included ages 14-45 years and up to 20 weeks gestational age. Exclusion criteria included history of psychogenic nonepileptic spells, expected intelligence quotient (IQ) <70, other major medical illness, progressive cerebral disease, and switching AEDs in pregnancy prior to enrollment.
resultsThree hundred fifty-one PWWE were enrolled in the MONEAD study, which included 259 (73.8%) on monotherapy, 77 (21.9%) on polytherapy, and 15 (4.3%) on no AEDs. The most common AED monotherapy regimens were lamotrigine (42.1% of monotherapies), levetiracetam (37.5%), carbamazepine (5.4%), zonisamide (5.0%), oxcarbazepine (4.6%), and topiramate (3.1%). All other individual monotherapies were each <1%. The most common AED polytherapy combination was lamotrigine + levetiracetam (42.9% of polytherapies), followed by lacosamide + levetiracetam (6.5%), lamotrigine + zonisamide (5.2%), and all other remaining combinations (each <4%); only 5.2% of polytherapy subjects were on ≥3 AEDs (1.1% of total PWWE). Only four subjects (1.1%) were on valproate (1 monotherapy, 3 polytherapy).
conclusionsThe distribution of AED use likely reflects current prescribing patterns for PWWE cared for in USA tertiary epilepsy centers. This distribution has changed markedly since the turn of the century, but changes in the general population remain uncertain.
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