Evidence map›Paper›PMID 29729997›Full record

ReviewTrends in biotechnology2018

Cold Plasmas for Biofilm Control: Opportunities and Challenges.

Brendan F Gilmore, Padrig B Flynn, Séamus O'Brien, Noreen Hickok, Theresa Freeman, Paula Bourke

Open access · greenAbstract readReview
In one paragraph

Review in Trends in biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 178 citations in OpenAlex.

  1. Pooled it
  2. Beyond Bactericidal: Plasma Surface Engineering to Defeat Food Matrix-Conditioning Layers.Comprehensive reviews in food science and food safety · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. By any other name: searching for the right plasma nomenclature.IEEE transactions on radiation and plasma medical sciences · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Cold Atmospheric Pressure Plasma Solutions for Sustainable Food Packaging.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Brendan F GilmoreBiofilm and Pharmaceutical Microbiology Research Group, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. Electronic address: http://twitter.com/@BrendanFGilmore.
Padrig B FlynnBiofilm and Pharmaceutical Microbiology Research Group, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Séamus O'BrienBiofilm and Pharmaceutical Microbiology Research Group, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Noreen HickokDepartment of Orthopaedic Research, Sidney Kimmel Medical College of Thomas Jefferson University, Jefferson Medical College, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA.
Theresa FreemanDepartment of Orthopaedic Research, Sidney Kimmel Medical College of Thomas Jefferson University, Jefferson Medical College, 1015 Walnut Street, Suite 501, Philadelphia, PA 19107, USA.
Paula BourkePlasma Research Group, School of Food Science and Environmental Health, Dublin Institute of Technology, Marlborough Street, Dublin 1, Ireland.
Queen's University Belfast · GBThomas Jefferson University · US

Funding

Plasma-based therapies for bone infection: A tripartite USA/Northern Ireland/Republic of Ireland consortiumR01AR076941 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI BOURKE, PAULA, FREEMAN, THERESA A · 2020 to 2025
$3.3M
Preventing Spinal Infection: Ultrasound Triggered ProphylaxisR01AR069119 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI Flemming Forsberg, Noreen J Hickok · 2016 to 2026
$3.2M
Smart Substrates for a New Generation of ImplantsR01AR051303 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI SHAPIRO, IRVING M · 2005 to 2009
$3.1M
Synovial Fluid and Joint SepsisR01AR072513 · NIAMS · THOMAS JEFFERSON UNIVERSITY · PI HICKOK, NOREEN J · 2017 to 2021
$2.5M
Non-Thermal Plasma in Biomedicine: A New Paradigm for Redox Cell ActivationR01EB013011 · NIBIB · THOMAS JEFFERSON UNIVERSITY · PI FREEMAN, THERESA A · 2011 to 2014
$1.4M
NIAMS NIH HHS R01 AR051303NIAMS NIH HHS R01 AR069119NIAMS NIH HHS R01 AR072513NIAMS NIH HHS R01 AR076941NIBIB NIH HHS R01 EB013011
6 · The paper itself

Abstract

Bacterial biofilm infections account for a major proportion of chronic and medical device associated infections in humans, yet our ability to control them is compromised by their inherent tolerance to antimicrobial agents. Cold atmospheric plasma (CAP) represents a promising therapeutic option. CAP treatment of microbial biofilms represents the convergence of two complex phenomena: the production of a chemically diverse mixture of reactive species and intermediates, and their interaction with a heterogeneous 3D interface created by the biofilm extracellular polymeric matrix. Therefore, understanding these interactions and physiological responses to CAP exposure are central to effective management of infectious biofilms. We review the unique opportunities and challenges for translating CAP to the management of biofilms.

Indexed as

Anti-Bacterial AgentsBacteriaBacterial InfectionsDNA, BacterialDrug Resistance, Multiple, BacterialExtracellular Polymeric Substance MatrixHumansLipidsMicrobial Sensitivity TestsPlasma GasesPolysaccharides, BacterialQuorum SensingReactive Nitrogen SpeciesReactive Oxygen SpeciesAnti-Bacterial AgentsDNA, BacterialLipidsPlasma GasesPolysaccharides, BacterialReactive Nitrogen SpeciesReactive Oxygen Species

Identifiers

PMID29729997
PMCPMC12168448
OpenAlexW2799670296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.