ArticleMagnetic resonance imaging2018
Pancreatic stiffness response to an oral glucose load in obese adults measured by magnetic resonance elastography.
Article in Magnetic resonance imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Practical and clinical applications of pancreatic magnetic resonance elastography: a systematic review.Abdominal radiology (New York) · 2021Pooled it
- Cross-sectional imaging of the pancreas in diabetes.Abdominal radiology (New York) · 2024Review
- Building Biomimetic Potency Tests for Islet Transplantation.Diabetes · 2021Review
- Normative Pancreatic Stiffness Levels and Related Influences Established by Magnetic Resonance Elastography in Volunteers.Journal of magnetic resonance imaging : JMRI · 2020Article
- Quantitative Magnetic Resonance Imaging of the Pancreas of Individuals With Diabetes.Frontiers in endocrinology · 2020Review
- Quantitative pancreatic MRI: a pathology-based review.The British journal of radiology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundTo test the feasibility of magnetic resonance elastography (MRE) for assessing changes in pancreatic stiffness of obese adults administered an oral glucose load.
methodsMRE scans were performed on 21 asymptomatic obese volunteers (BMI ≥ 27 kg/m
resultsGood inter-observer agreement was found for image quality at both frequencies (kappa = 0.805 for 40 Hz and 0.762 for 60 Hz). The median overall image quality score was significantly higher in 40 Hz than that of 60 Hz (4 versus 2). At 40 Hz, pancreatic stiffness in response to oral glucose had a decrease of 6.7% (pre vs post: 1.17 ± 0.13 kPa vs 1.08 ± 0.12 kPa; P < 0.001), whereas the change in stiffness was not significant at 60 Hz (pre vs post: 2.01 ± 0.21 kPa vs 2.02 ± 0.24 kPa; P = 0.695). Excellent intersession agreement was found for MRE acquisitions at 40 Hz with an overall intraclass correlation coefficient = 0.947 (95% confidence interval: 0.913-0.967).
conclusionMRE at 40 Hz provides good-quality wave images and high sensitivity to changes in the mechanical properties of pancreatic tissue in obese volunteers after an oral glucose load.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.