Evidence map›Paper›PMID 29729651›Full record

ArticleJournal of thrombosis and haemostasis : JTH2018

Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage.

H Wan, Y Wang, J Ai, S Brathwaite, H Ni, R L Macdonald, E M Hol, J C M Meijers, M D I Vergouwen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Mouse models to study von Willebrand factor in thrombosis: a scoping review.Research and practice in thrombosis and haemostasis · 2026
    Article
  2. Microthrombi and hypercoagulability's contribution to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Immunological Profile of Vasospasm after Subarachnoid Hemorrhage.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Role of platelets in the pathogenesis of delayed injury after subarachnoid hemorrhage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Review
  15. Review
  16. Neuroprotective Strategies in Aneurysmal Subarachnoid Hemorrhage (aSAH).International journal of molecular sciences · 2021
    Review
  17. Biochemical Parameters in Cognitive Functions.Neuropsychiatric disease and treatment · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

H WanDivision of Neurosurgery, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Y WangKeenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute of St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
J AiDivision of Neurosurgery, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
S BrathwaiteDivision of Neurosurgery, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
H NiKeenan Research Centre for Biomedical Science and the Li Ka Shing Knowledge Institute of St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
R L MacdonaldDivision of Neurosurgery, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
E M HolBrain Center Rudolf Magnus, Department of Translational Neurosciences, University Medical Center Utrecht, Utrecht, The Netherlands.
J C M MeijersDepartment of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands.ORCID 0000-0002-4198-6780
M D I VergouwenBrain Center Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, the Netherlands.

Funding

CIHR
6 · The paper itself

Abstract

Essentials von Willebrand Factor (VWF) and ADAMTS13 may affect early injury after subarachnoid hemorrhage (SAH). Early brain injury was assessed in VWF SUMMARY: Background Early brain injury is an important determinant of poor functional outcome and case fatality after aneurysmal subarachnoid hemorrhage (SAH), and is associated with early platelet aggregation. No treatment exists for early brain injury after SAH. We investigated whether von Willebrand factor (VWF) is involved in the pathogenesis of early brain injury, and whether ultra-early treatment with recombinant ADAMTS-13 (rADAMTS-13) reduces early brain injury after experimental SAH. Methods Experimental SAH in mice was induced by prechiasmatic injection of non-anticoagulated blood from a littermate. The following experimental SAH groups were investigated: C57BL/6J control (n = 21), VWF

Indexed as

ADAMTS13 ProteinAnimalsApoptosisBrainBrain InjuriesCalcium-Binding ProteinsCaspase 3Disease Models, AnimalDrug Administration ScheduleFemaleGenetic Predisposition to DiseaseMaleMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsMicrogliaADAMTS13 ProteinADAMTS13 protein, mouseAif1 protein, mouseCalcium-Binding ProteinsCasp3 protein, mouseCaspase 3Microfilament ProteinsNeuroprotective AgentsRecombinant Proteinsvon Willebrand Factorbrain diseasesplatelet aggregationsubarachnoid hemorrhagethrombosisvon Willebrand factor

Identifiers

PMID29729651
PMCPMC6055612

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.