ArticleThe Annals of thoracic surgery2018
Treatment Approaches and Outcomes for Primary Mediastinal Sarcoma: Analysis of 976 Patients.
Article in The Annals of thoracic surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Prognostic Factors and Survival Outcomes in Resectable Thoracic Soft Tissue and Bone Sarcomas.Cancers · 2026Article
- Safety and feasibility of a novel bronchoplasty-based approach for the resection of middle mediastinal tumors located beneath the carina: a real-world study.Journal of thoracic disease · 2026Article
- Primary Mediastinal Osteosarcoma: A Rare and Aggressive Tumour in an Unusual Location.European journal of case reports in internal medicine · 2026Article
- Management and outcomes of thoracic sarcomas - a collaboration between Orthopaedic Oncology and cardiothoracic surgery: seven-year clinical data from a tertiary referral centre.Journal of cardiothoracic surgery · 2025Article
- Primary Mediastinal Ewing's Sarcoma: Post Hoc Analysis from Two International Multicenter Prospective Randomized Trials.Cancers · 2025Article
- Primary leiomyosarcoma originating from the azygos vein misdiagnosed as tracheal tumor: a case report and literature review.Frontiers in oncology · 2025Article
- Head to head comparison ofEuropean radiology · 2024Article
- A rare case of a young man with mediastinal synovial sarcoma.Respiratory medicine case reports · 2024Article
- A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager.Frontiers in oncology · 2024Article
- Surgically Resected Cardiac Angiosarcoma: Survival Analysis from the National Cancer Database.Journal of clinical medicine · 2023Article
- Mediastinal Synovial Sarcoma 14 Years After Talc Pleurodesis for Spontaneous Pneumothorax.Annals of thoracic surgery short reports · 2023Article
- Application of Artificial Intelligence in the Diagnosis, Treatment, and Prognostic Evaluation of Mediastinal Malignant Tumors.Journal of clinical medicine · 2023Review
- Giant middle mediastinal lesions: when tumor size correlates with mesenchymal origin-a retrospective single-center analysis.Mediastinum (Hong Kong, China) · 2023Article
- Proton Beam Therapy for Unresectable Mediastinal and Pericardial Spindle Cell Sarcoma: A Case Report.International journal of particle therapy · 2023Article
- Posterior mediastinal epithelioid leiomyosarcoma: Case report and literature review.Radiology case reports · 2022Article
- A case report of a giant middle mediastinal leiomyosarcoma.Mediastinum (Hong Kong, China) · 2022Article
- Survival predictors of metastatic angiosarcomas: a surveillance, epidemiology, and end results program population-based retrospective study.BMC cancer · 2020Article
- The role of molecular pathology in mediastinal sarcomas.Mediastinum (Hong Kong, China) · 2020Review
- Vascular tumors of the mediastinum.Mediastinum (Hong Kong, China) · 2020Review
- Mediastinal soft tissue sarcoma: dark sides and future lights.Mediastinum (Hong Kong, China) · 2020Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrimary mediastinal sarcomas are rare and deadly. Our objective was to describe the clinicopathological features, treatment strategies, and overall survival outcomes for a contemporary cohort of patients diagnosed with primary mediastinal sarcoma in the United States.
methodsWe queried the National Cancer Database for cases of mediastinal sarcoma diagnosed from 2004 to 2012. Five-year overall survival (OS) was examined using the Kaplan-Meier method. Differences in OS were assessed using log-rank analysis and Cox proportional hazards regression.
resultsThe mean age of diagnosis was 53 years (range, 0 to 90) with a male predominance (59.2%). The most common histological subtype was hemangiosarcoma (27.1%). Fewer than half of patients underwent surgery (48.9%), and 19.7% of patients had no treatment. For all patients, OS was 14.8%. The best unadjusted OS was seen in patients treated with surgery and radiation (40.1%); untreated patients had the worst unadjusted OS (4.2%). Of those who underwent surgery (n = 477, 48.9%), OS was significantly better for those who achieved an R0 resection (30.1% versus 18.9%; p = 0.002). In multivariable analysis, surgery combined with radiation therapy was again associated with the best survival (HR, 0.24; 95% CI, 0.16 to 0.36). Other factors associated with improved OS included younger age, fewer comorbidities, and leiomyosarcoma histology. Worse OS was associated with poorly differentiated or undifferentiated grade, metastases, treatment in the New England region, and having Medicaid or no insurance. Sex and tumor size had no effect on OS.
conclusionsThe 5-year OS for primary mediastinal sarcoma is poor. Surgical resection can be successful and should be considered whenever possible.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.