ArticleDevelopmental biology2018
Insulin signaling acts in adult adipocytes via GSK-3β and independently of FOXO to control Drosophila female germline stem cell numbers.
Article in Developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 71 citations in OpenAlex.
- Microbe-dependent inter-organ communication regulates germline stem cell proliferation inbioRxiv : the preprint server for biology · 2026Article
- Molecular evidence for early deuterostome origins of ovarian cell types and neuroendocrine control of reproduction.Nature communications · 2026Article
- Article
- Estrogen-related receptor is required in adult Drosophila females for germline stem cell maintenance.Developmental biology · 2025Article
- Review
- Adipocyte-DerivedBiomolecules · 2025Article
- Traumatic injury leads to ovarian cell death and reproductive disturbances in Drosophila melanogaster.Biology open · 2025Article
- Insulin Signaling Pathway Mediates FoxO-Pepck Axis Regulation of Glucose Homeostasis inInternational journal of molecular sciences · 2024Article
- Improved whole-mount immunofluorescence protocol for consistent and robust labeling of adult Drosophila melanogaster adipose tissue.Biology open · 2024Article
- Integrated stress response signaling acts as a metabolic sensor in fat tissues to regulate oocyte maturation and ovulation.Cell reports · 2024Article
- Mating-induced increase of kynurenine in Drosophila ovary enhances starvation resistance of progeny.The Journal of biological chemistry · 2024Article
- Article
- Differential amino acid transporter expression in adultmicroPublication biology · 2024Article
- Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways.Communications biology · 2023Article
- Spatio-temporal patterns of ovarian development andOpen biology · 2023Article
- Untargeted Lipidomics Analysis Unravels the Different Metabolites in the Fat Body of Mated Bumblebee (International journal of molecular sciences · 2023Article
- A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster.Development (Cambridge, England) · 2023Article
- Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Methods to Analyze Nutritional and Inter-Organ Control of Drosophila Ovarian Germline Stem Cells.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Interactions between innate immunity and insulin signaling affect resistance to infection in insects.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tissue-specific stem cells are tied to the nutritional and physiological environment of adult organisms. Adipocytes have key endocrine and nutrient-sensing roles and have emerged as major players in relaying dietary information to regulate other organs. For example, previous studies in Drosophila melanogaster revealed that amino acid sensing as well as diet-dependent metabolic pathways function in adipocytes to influence the maintenance of female germline stem cells (GSCs). How nutrient-sensing pathways acting within adipocytes influence adult stem cell lineages, however, is just beginning to be elucidated. Here, we report that insulin/insulin-like growth factor signaling in adipocytes promotes GSC maintenance, early germline cyst survival, and vitellogenesis. Further, adipocytes use distinct mechanisms downstream of insulin receptor activation to control these aspects of oogenesis, all of which are independent of FOXO. We find that GSC maintenance is modulated by Akt1 through GSK-3β, early germline cyst survival is downstream of adipocyte Akt1 but independent of GSK-3β, and vitellogenesis is regulated through an Akt1-independent pathway in adipocytes. These results indicate that, in addition to employing different types of nutrient sensing, adipocytes can use distinct axes of a single nutrient-sensing pathway to regulate multiple stages of the GSC lineage in the ovary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.