ArticleThe British journal of dermatology2018
The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis.
Article in The British journal of dermatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- The Skin Microbiome of Patients With Atopic Dermatitis Normalizes Gradually During Treatment.Frontiers in cellular and infection microbiology · 2021Trial
- Genomic epidemiology and phenotypic characterization of Staphylococcus aureus isolated from atopic dermatitis patients in South China.Scientific reports · 2025Article
- Vaccines in Dermatology-Present and Future: A Review.Vaccines · 2025Review
- The mutational landscape of Staphylococcus aureus during colonisation.Nature communications · 2025Article
- Observational
- Understanding the role ofFrontiers in medicine · 2024Review
- Investigating genomic diversity ofFrontiers in microbiology · 2024Article
- In Vitro Effect ofVeterinary sciences · 2023Article
- Staphylococcus aureus from Atopic Dermatitis Patients: Its Genetic Structure and Susceptibility to Phototreatment.Microbiology spectrum · 2023Article
- Staphylococcal diversity in atopic dermatitis from an individual to a global scale.Cell host & microbe · 2023Article
- On-person adaptive evolution of Staphylococcus aureus during treatment for atopic dermatitis.Cell host & microbe · 2023Article
- Prescription Patterns of Topical Medications in Patients with Atopic Dermatitis: An Investigative Review Using Big Data from the National Health Insurance Corporation.Annals of dermatology · 2023Article
- Plectasin: from evolution to truncation, expression, and better druggability.Frontiers in microbiology · 2023Article
- Microbial manipulation in atopic dermatitis.Clinical and translational medicine · 2022Article
- The Human Skin Microbiome in Selected Cutaneous Diseases.Frontiers in cellular and infection microbiology · 2022Review
- From Emollients to Biologicals: Targeting Atopic Dermatitis.International journal of molecular sciences · 2021Review
- The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis-An Update.International journal of molecular sciences · 2021Review
- Distinct expression profiles of regulatory RNAs in the response to biocides in Staphylococcus aureus and Enterococcus faecium.Scientific reports · 2021Article
- Staphylococcal Communities on Skin Are Associated with Atopic Dermatitis and Disease Severity.Microorganisms · 2021Article
- Skin Microbiome in Atopic Dermatitis.Acta dermato-venereologica · 2020Review
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13 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundCarriage rates of Staphylococcus aureus on affected skin in atopic dermatitis (AD) are approximately 70%. Increasing disease severity during flares and overall disease severity correlate with increased burden of S. aureus. Treatment in AD therefore often targets S. aureus with topical and systemic antimicrobials.
objectivesTo determine whether antimicrobial sensitivities and genetic determinants of resistance differed in S. aureus isolates from the skin of children with AD and healthy child nasal carriers.
methodsIn this case-control study, we compared S. aureus isolates from children with AD (n = 50) attending a hospital dermatology department against nasal carriage isolates from children without skin disease (n = 49) attending a hospital emergency department for noninfective conditions. Using whole genome sequencing we generated a phylogenetic framework for the isolates based on variation in the core genome, then compared antimicrobial resistance phenotypes and genotypes between disease groups.
resultsStaphylococcus aureus from cases and controls had on average similar numbers of phenotypic resistances per isolate. Case isolates differed in their resistance patterns, with fusidic acid resistance (Fus
conclusionsThe results suggest that strong selective pressure drives the emergence and maintenance of specific resistances in AD.
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