Evidence map›Paper›PMID 29728946›Full record

ArticleJournal of autism and developmental disorders2018

Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder.

Molly B D Prigge, Erin D Bigler, Brittany G Travers, Alyson Froehlich, Tracy Abildskov, Jeffrey S Anderson, Andrew L Alexander, Nicholas Lange, Janet E Lainhart, Brandon A Zielinski

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Linking Brain Morphometry to Psychometric Measures and Energy-Metabolic Biomarkers in Adults With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Molly B D PriggeDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA. molly.prigge@hsc.utah.edu.
Erin D BiglerDepartments of Psychology and Neuroscience, Brigham Young University, Provo, UT, USA.
Brittany G TraversWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Alyson FroehlichDepartment of Psychology, University of Utah, Salt Lake City, UT, USA.
Tracy AbildskovDepartments of Psychology and Neuroscience, Brigham Young University, Provo, UT, USA.
Jeffrey S AndersonDepartment of Radiology, University of Utah, Salt Lake City, UT, USA.
Andrew L AlexanderWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Nicholas LangeMcLean Hospital and Department of Psychiatry, Harvard University, Cambridge, MA, USA.
Janet E LainhartWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Brandon A ZielinskiDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
University of Utah · USUniversity of Wisconsin–Madison · USBrigham Young University · USMcLean Hospital · US

Funding

Atypical Late Neurodevelopment in Autism: A Longitudinal MRI and DTI StudyR01MH080826 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI LAINHART, JANET ELIZABETH · 2007 to 2020
$6.5M
POSTDOCTORAL TRAINING IN MENTAL RETARDATION RESEARCHT32HD007489 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Sigan L Hartley · 1995 to 2026
$6.0M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI POLLAK, SETH D · 2016 to 2020
$6.0M
Biological Determinants of Brain Variation in AutismR01MH097464 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI LAINHART, JANET ELIZABETH, LANGE, NICHOLAS T · 2013 to 2017
$2.9M
The Microstructural Basis of Abnormal Connectivity in AutismR01MH084795 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI LAINHART, JANET ELIZABETH · 2009 to 2013
$1.9M
Longitudinal Characterization of Functional Connectivity in AutismK08MH092697 · NIMH · UNIVERSITY OF UTAH · PI ANDERSON, JEFFREY · 2011 to 2015
$912k
Brain Network Development in Normal and Autistic ChildrenK08MH100609 · NIMH · UNIVERSITY OF UTAH · PI ZIELINSKI, BRANDON A. · 2014 to 2017
$759k
Eunice Kennedy Shriver National Institute of Child Health and Human Development T32 HD007489Eunice Kennedy Shriver National Institute of Child Health and Human Development U54 HD090256National Institute of Mental Health K08 MH092697National Institute of Mental Health K08 MH100609National Institute of Mental Health R01 MH080826National Institute of Mental Health R01 MH084795National Institute of Mental Health R01 MH097464NICHD NIH HHS T32 HD007489NICHD NIH HHS U54 HD090256NIMH NIH HHS K08 MH092697NIMH NIH HHS K08 MH100609NIMH NIH HHS R01 MH080826NIMH NIH HHS R01 MH084795NIMH NIH HHS R01 MH097464
6 · The paper itself

Abstract

The relationship between brain development and clinical heterogeneity in autism (ASD) is unknown. This study examines the Social Responsiveness Scale (SRS) in relation to the longitudinal development of cortical thickness. Participants (N = 91 ASD, N = 56 TDC; 3-39 years at first scan) were scanned up to three times over a 7-year period. Mixed-effects models examined cortical thickness in relation to SRS score. ASD participants with higher SRS scores showed regionally increased age-related cortical thinning. Regional thickness differences and reduced age-related cortical thinning were found in predominantly right lateralized regions in ASD with decreasing SRS scores over time. Our findings emphasize the importance of examining clinical phenotypes in brain-based studies of ASD.

Indexed as

Interpersonal RelationsAdolescentAdultAutism Spectrum DisorderCerebral CortexChildChild, PreschoolCohort StudiesFemaleHumansLongitudinal StudiesMaleOrgan SizeYoung AdultAutism severityAutism spectrum disorder (ASD)Brain developmentCortical thicknessLongitudinalSocial Responsiveness Scale (SRS)

Identifiers

PMID29728946
PMCPMC6143416
OpenAlexW2799430798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.