Evidence map›Paper›PMID 29728916›Full record

ArticleAmino acids2018

Influence of composition of cysteine-containing peptide-based chelators on biodistribution of

Maryam Oroujeni, Ken G Andersson, Xenia Steinhardt, Mohamed Altai, Anna Orlova, Bogdan Mitran, Anzhelika Vorobyeva, Javad Garousi, Vladimir Tolmachev, John Löfblom

Abstract read
In one paragraph

Article in Amino acids, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Novel smallFrontiers in oncology · 2022
    Article
  6. PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology.International journal of molecular sciences · 2021
    Review
  7. Preclinical Evaluation ofInternational journal of molecular sciences · 2021
    Article
  8. Review
  9. Review
  10. Increase in negative charge ofScientific reports · 2019
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maryam OroujeniDepartment of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden.
Ken G AnderssonDepartment of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden.
Xenia SteinhardtDepartment of Protein Science, KTH-Royal Institute of Technology, Stockholm, Sweden.
Mohamed AltaiDepartment of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden.
Anna OrlovaDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Bogdan MitranDepartment of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Anzhelika VorobyevaDepartment of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden.
Javad GarousiDepartment of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden.
Vladimir TolmachevDepartment of Immunology, Genetics and Pathology, Uppsala University, 75181, Uppsala, Sweden. vladimir.tolmachev@igp.uu.se.ORCID http://orcid.org/0000-0002-6122-1734
John LöfblomDepartment of Protein Science, KTH-Royal Institute of Technology, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidermal growth factor receptor (EGFR) is overexpressed in a number of cancers and is the molecular target for several anti-cancer therapeutics. Radionuclide molecular imaging of EGFR expression should enable personalization of anti-cancer treatment. Affibody molecule is a promising type of high-affinity imaging probes based on a non-immunoglobulin scaffold. A series of derivatives of the anti-EGFR affibody molecule ZEGFR:2377, having peptide-based cysteine-containing chelators for conjugation of

Indexed as

Molecular ImagingAnimalsCell Line, TumorChelating AgentsCysteineErbB ReceptorsHumansMiceMolecular ProbesNeoplasmsNeoplasm TransplantationPeptidesRecombinant Fusion ProteinsTechnetiumTissue DistributionChelating AgentsCysteineEGFR protein, humanErbB ReceptorsMolecular ProbesPeptidesRecombinant Fusion ProteinsTechnetiumTechnetium-9999mTcAffibody moleculesEGFRGlutamatePeptide-based chelators

Identifiers

PMID29728916
PMCPMC6060960

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.