ArticleAmino acids2018
Prediction and characterization of a novel hemocyanin-derived antimicrobial peptide from shrimp Litopenaeus vannamei.
Article in Amino acids, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Marine Antimicrobial Peptides: From Ocean Biodiversity to Genome Mining, Multi-Omics Discovery, and Biotechnological Innovation in the Battle Against Antimicrobial Resistance.Probiotics and antimicrobial proteins · 2026Review
- Article
- Aquatic Invertebrate Antimicrobial Peptides in the Fight Against Aquaculture Pathogens.Microorganisms · 2025Review
- Hemolymph microbiota and host immunity of crustaceans and mollusks.The ISME journal · 2025Review
- Shrimp hemocyanin elicits a potent humoral response in mammals and is favorable to hapten conjugation.Scientific reports · 2024Article
- Antibacterial Properties of Peptide and Protein Fractions fromMolecules (Basel, Switzerland) · 2024Article
- Antibacterial Action of Protein Fraction Isolated fromPharmaceuticals (Basel, Switzerland) · 2024Article
- Health-Promoting Additives Supplemented in Inert Microdiets for Whiteleg Shrimp (Animals : an open access journal from MDPI · 2023Article
- Preparation, Purification and Characterization of Antibacterial and ACE Inhibitory Peptides from Head Protein Hydrolysate of Kuruma Shrimp,Molecules (Basel, Switzerland) · 2023Article
- CAMPR4: a database of natural and synthetic antimicrobial peptides.Nucleic acids research · 2023Article
- Prediction and bioactivity of small-molecule antimicrobial peptides fromFrontiers in microbiology · 2023Article
- Marine Arthropods as a Source of Antimicrobial Peptides.Marine drugs · 2022Review
- Functional Characterization, Antimicrobial Effects, and Potential Antibacterial Mechanisms ofMarine drugs · 2022Article
- LvHemB1, a novel cationic antimicrobial peptide derived from the hemocyanin of Litopenaeus vannamei, induces cancer cell death by targeting mitochondrial voltage-dependent anion channel 1.Cell biology and toxicology · 2022Article
- Protein Diversity and Immune Specificity of Hemocyanin From ShrimpFrontiers in immunology · 2021Article
- Collection of antimicrobial peptides database and its derivatives: Applications and beyond.Protein science : a publication of the Protein Society · 2020Article
- AMolecules (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Hemocyanin, the multifunctional glycoprotein in the hemolymph of invertebrates, can generate various antimicrobial peptides (AMPs). Given the rising interest in the use of natural therapeutic agents such as AMPs, alternative and more efficient methods for their generation are being explored. In this work, free online software was first applied to predict the generation of antimicrobial peptides from the large subunit of Litopenaeus vannamei hemocyanin. Twenty potential antimicrobial peptides ranging from 1.5 to 1.9 kDa were predicted, five of which had α-helical structures and were selected for antibacterial activity testing. The results indicated that these five peptides had antibacterial activity against seven different bacteria. Of the five peptides, one peptide, designated L1, had the strongest antibacterial activity against both Gram-negative and Gram-positive bacteria. Moreover, CD and NMR data showed that L1 had both α-helical and β-turns structural composition, and that these structures were essential for L1's antibacterial activity. Furthermore, SEM analysis revealed that peptide L1 had broad-spectrum activity against both Gram-positive and Gram-negative bacteria, as it could destroy the bacterial cell walls and kill the bacteria. Thus, L1 is a very potent antimicrobial peptide that can be exploited and used in antibacterial therapeutics.
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Registered trials
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