Evidence map›Paper›PMID 29728831›Full record

Observational studyClinical research in cardiology : official journal of the German Cardiac Society2018

Time trends in characteristics, clinical course, and outcomes of 13,791 patients with acute heart failure.

Pere Llorens, Patricia Javaloyes, Francisco Javier Martín-Sánchez, Javier Jacob, Pablo Herrero-Puente, Víctor Gil, José Manuel Garrido, Eva Salvo, Marta Fuentes, Héctor Alonso and 7 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Trial
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  14. QT interval and short-term outcome in acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Article
  15. Observational
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Pere LlorensEmergency Department, Short Stay Unit and Hospitalization at Home, ISABIAL-Fundación FISABIO, Hospital Universitario General de Alicante, Alicante, Spain.
Patricia JavaloyesEmergency Department, Short Stay Unit and Hospitalization at Home, ISABIAL-Fundación FISABIO, Hospital Universitario General de Alicante, Alicante, Spain.
Francisco Javier Martín-SánchezEmergency Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitario Hospital Clínico San Carlos (IdISSC), Complutense University of Madrid, Madrid, Spain.
Javier JacobEmergency Department, Hospital Universitario de Bellvitge, Barcelona, Spain.
Pablo Herrero-PuenteEmergency Department, Grupo de Investigación de Urgencias-HUCA, Hospital Universitario Central de Asturias, Oviedo, Spain.
Víctor Gil"Emergencies: Processes and Pathologies" Research Group, Emergency Department, IDIBAPS, Hospital Clínic, Barcelona, Villarroel 170, 08036, Barcelona, Catalonia, Spain.
José Manuel GarridoEmergency Department, Hospital Virgen de la Macarena, Seville, Spain.
Eva SalvoEmergency Department, Hospital Politécnico La Fe, Valencia, Spain.
Marta FuentesEmergency Department, Hospital Universitario de Salamanca, Salamanca, Spain.
Héctor AlonsoEmergency Department, Hospital Marqués de Valdecilla, Santander, Spain.
Fernando RichardEmergency Department, Hospital Universitario de Burgos, Burgos, Spain.
Francisco Javier LucasEmergency Department, Hospital General de Albacete, Albacete, Spain.
Héctor BuenoCardiology Department, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain.
John ParissisSecond Department of Cardiology, University of Athens Medical School, Athens, Greece.
Christian E MüllerCardiology Department, University Hospital of Basel, Basel, Switzerland.
Òscar MiróThe GREAT (Global REsearch on Acute conditions Team) Network, Rome, Italy. omiro@clinic.cat.
ICA-SEMES Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo analyse time trends in patient characteristics, clinical course, hospitalisation rate, and outcomes in acute heart failure along a 10-year period (2007-2016).

methodsThe EAHFE registry has prospectively collected 13,971 consecutive AHF patients diagnosed in 41 Spanish emergency departments (EDs) at five different time points (2007/2009/2011/2014/2016). Eighty patient-related variables and outcomes were described and statistically significant changes along time were evaluated. We also compared our data with large ED- and hospital-based registries.

resultsCompared to other large registries, our patients were older [80 (10) years], more frequently women (55.5%), and had a higher prevalence of hypertension (83.5%) and a lower prevalence of ischaemic cardiomyopathy (29.4%). De novo AHF was observed in 39.6%. 63.6% showed some degree of functional dependence and 56.1% had preserved left ventricular ejection fraction (LVEF). 56.8% of the patients arrived at the ED by ambulance, 4.5% arrived hypotensive, and 21.3% hypertensive. Direct discharge from the ED home was seen in 24.9%, and internal medicine (32.5%) and cardiology (15.8%) were the main hospital destinations. Triggers for decompensation were identified in 75.4%, the most being frequent infection (35.2%) and rapid atrial fibrillation (14.7%). The AHF phenotypes were: warm/wet 82.0%, warm/dry 6.2%, cold/wet 11.1%, and cold/dry 0.7%. The length of hospitalisation was 9.3 (8.6) days, and in-hospital, 30-day, and 1-year all-cause mortality were 7.8, 10.2 and 30.3%, respectively; and 30-day re-hospitalisation and ED revisit due to AHF were 16.9 and 24.8%, respectively. Thirty-nine of the eighty characteristics studied showed significant changes over time, while all outcomes remained unchanged along the 10-year period.

conclusionsThe EAHFE Registry is the first European ED-based registry describing the characteristics, clinical course, and outcomes of a cohort resembling the universe of patients with AHF. Significant changes were observed over time in some aspects of AHF characteristics and management, but not in outcomes.

Indexed as

RegistriesAcute DiseaseAged, 80 and overDisease ProgressionEmergency Service, HospitalFemaleFollow-Up StudiesHeart FailureHospitalizationHospital MortalityHumansMaleMorbidityPrognosisProspective StudiesSpainAcute heart failureEpidemiologyMortalityOutcomeRegistry

Identifiers

PMID29728831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.