ArticlePediatric radiology2018
Free-breathing quantification of hepatic fat in healthy children and children with nonalcoholic fatty liver disease using a multi-echo 3-D stack-of-radial MRI technique.
Article in Pediatric radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Free-Breathing Fat Quantification Using a Phase Error-Corrected Cartesian Acquisition With Spiral Profile Ordering.Magnetic resonance in medicine · 2026Article
- Generalized U-Net for automatic liver segmentation and R2* estimation for assessment of iron overload using MRI.BMC medical imaging · 2026Article
- Accelerated free-breathing volumetric liver proton density fat fraction (PDFF) andMagma (New York, N.Y.) · 2026Article
- Free-Breathing Hybrid Technique for Simultaneous Morphological and Quantitative Abdominal Imaging at 0.55 T.Investigative radiology · 2026Article
- Cross-cohort federated learning for pediatric abdominal adipose tissue segmentation and quantification using free-breathing 3D MRI.Radiology advances · 2026Article
- Advancing free-breathing liver diffusion-weighted imaging with Propeller-EPI: Improved image quality and ADC repeatability.Medical physics · 2025Article
- Rapid, high-resolution and distortion-freeMagnetic resonance in medicine · 2025Article
- Rapid, High-resolution and Distortion-freeArXiv · 2025Article
- State-of-the-Art Quantification of Liver Iron With MRI-Vendor Implementation and Available Tools.Journal of magnetic resonance imaging : JMRI · 2025Review
- Practical approach to quantitative liver and pancreas MRI in children.Pediatric radiology · 2025Review
- MASLD: What We Have Learned and Where We Need to Go-A Call to Action.Radiographics : a review publication of the Radiological Society of North America, Inc · 2024Review
- Reproducibility of ultrasound-derived fat fraction in measuring hepatic steatosis.Insights into imaging · 2024Article
- Free-breathing MRI techniques for fat and RMagma (New York, N.Y.) · 2024Review
- Clinical Application of Quantitative MR Imaging in Nonalcoholic Fatty Liver Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Review
- Uncertainty-aware physics-driven deep learning network for free-breathing liver fat and RMagnetic resonance in medicine · 2023Article
- Liver cirrhosis in children - the role of imaging in the diagnostic pathway.Pediatric radiology · 2023Article
- Undersampling artifact reduction for free-breathing 3D stack-of-radial MRI based on a deep adversarial learning network.Magnetic resonance imaging · 2023Article
- Pregnancies complicated by gestational diabetes and fetal growth restriction: an analysis of maternal and fetal body composition using magnetic resonance imaging.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Free-breathing radial magnetic resonance elastography of the liver in children at 3 T: a pilot study.Pediatric radiology · 2022Article
- Hepatic Iron Quantification Using a Free-Breathing 3D Radial Gradient Echo Technique and Validation With a 2D Biopsy-Calibrated RJournal of magnetic resonance imaging : JMRI · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundIn adults, noninvasive chemical shift encoded Cartesian magnetic resonance imaging (MRI) and single-voxel magnetic resonance (MR) spectroscopy (SVS) accurately quantify hepatic steatosis but require breath-holding. In children, especially young and sick children, breath-holding is often limited or not feasible. Sedation can facilitate breath-holding but is highly undesirable. For these reasons, there is a need to develop free-breathing MRI technology that accurately quantifies steatosis in all children.
objectiveThis study aimed to compare non-sedated free-breathing multi-echo 3-D stack-of-radial (radial) MRI versus standard breath-holding MRI and SVS techniques in a group of children for fat quantification with respect to image quality, accuracy and repeatability. MATERIALS AND
methodsHealthy children (n=10, median age [±interquartile range]: 10.9 [±3.3] years) and overweight children with nonalcoholic fatty liver disease (NAFLD) (n=9, median age: 15.2 [±3.2] years) were imaged at 3 Tesla using free-breathing radial MRI, breath-holding Cartesian MRI and breath-holding SVS. Acquisitions were performed twice to assess repeatability (within-subject mean difference, MD
resultsIn patients with NAFLD, free-breathing radial MRI demonstrated significantly less motion artifacts compared to breath-holding Cartesian (P<0.05). Free-breathing radial PDFF demonstrated a linear relationship (P<0.001) versus breath-holding SVS PDFF and breath-holding Cartesian PDFF with r=0.996 and ρ
conclusionIn this pediatric study, non-sedated free-breathing radial MRI provided accurate and repeatable hepatic PDFF measurements and improved image quality, compared to standard breath-holding MR techniques.
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